000003073 001__ 3073
000003073 005__ 20231229071611.0
000003073 0247_ $$2DOI$$a10.6083/M4N29WH9
000003073 037__ $$aETD
000003073 245__ $$aToll-like receptor four and neutrophil contributions to endotoxemia - enhanced aminoglycoside ototoxicity
000003073 260__ $$bOregon Health and Science University
000003073 269__ $$a2018
000003073 336__ $$aDissertation
000003073 502__ $$bPh.D.
000003073 502__ $$gNeuroscience
000003073 520__ $$aDrug-Induced Ototoxicity is a widespread global problem occurring as a side effect of otherwise effective therapies for conditions such as bacterial sepsis (aminoglycosides) and cancers (platinum-based chemotherapy). It is becoming clear that having the conditions requiring these drugs itself puts the patient at increased risk for acquiring life-long hearing loss. This apparent clinical paradox places the provider in difficult position where treating the life-threatening condition will most likely result in poor hearing outcomes. Since these ototoxic therapies are both life-saving and economically viable, understanding the mechanisms of hearing loss and developing effective strategies to preserve hearing during treatment for life-threatening illness has the potential to greatly enhance the quality of life in vulnerable patient populations.
000003073 540__ $$fCC BY
000003073 542__ $$fIn copyright - single owner
000003073 650__ $$aHearing$$019916
000003073 650__ $$aCochlea$$016848
000003073 650__ $$aInflammation$$020800
000003073 6531_ $$atoxicity
000003073 691__ $$aSchool of Medicine$$041369
000003073 692__ $$aVollum Institute$$041509
000003073 7001_ $$aUrdang, Zachary$$uOregon Health and Science University$$041354
000003073 8564_ $$9a9cf32ca-3851-4d51-8463-e56e083308bb$$s5339040$$uhttps://digitalcollections.ohsu.edu/record/3073/files/4006_etd.pdf
000003073 905__ $$a/rest/prod/8c/97/kq/59/8c97kq59w
000003073 909CO $$ooai:digitalcollections.ohsu.edu:3073$$pstudent-work
000003073 980__ $$aTheses and Dissertations