@article{ETD,
      recid = {3078},
      author = {Sunderhaus, Elizabeth},
      title = {Identifying the pathogenic mechanisms of swiss-cheese  phenotypes to understand neuropathy target esterase  associated disorders},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2018-05-01},
      number = {ETD},
      abstract = {Neuropathy Target Esterase (NTE) is an enzyme localized to  the ER that regulates Protein Kinase A (PKA) signaling and  maintains lipid homeostasis. Exposure to a  neurotoxic  organophosphate or mutations in NTE cause a spectrum of  disorders with  neurodegenerative  symptoms  ranging  from   blindness,  hypogonadism, and cerebellar atrophy to motor  neuron loss. Understanding how the functions of NTE are   affected by a chemical or  mutations  and  the  mechanisms   of  pathology  is important  for  the identification of  pathways  and  development  of  therapeutic   strategies.  Loss of NTE’s ortholog, Swiss-Cheese (SWS), in Drosophila   melanogaster causes a dysregulation of PKA signaling, an  increase in  phosphatidylcholine (PC) and  lysophosphatidylcholine (LPC) levels and eventual  age-dependent neurodegeneration. The goal of this research  was to use Drosophila to understand the etiology of NTE  disorders.},
      url = {http://digitalcollections.ohsu.edu/record/3078},
      doi = {https://doi.org/10.6083/g4pr-1p73},
}