TY  - GEN
AB  - Neuropathy Target Esterase (NTE) is an enzyme localized to the ER that regulates Protein Kinase A (PKA) signaling and maintains lipid homeostasis. Exposure to a  neurotoxic organophosphate or mutations in NTE cause a spectrum of disorders with  neurodegenerative  symptoms  ranging  from  blindness,  hypogonadism, and cerebellar atrophy to motor neuron loss. Understanding how the functions of NTE are  affected by a chemical or  mutations  and  the  mechanisms  of  pathology  is important  for  the identification of pathways  and  development  of  therapeutic   strategies. Loss of NTE’s ortholog, Swiss-Cheese (SWS), in Drosophila  melanogaster causes a dysregulation of PKA signaling, an increase in  phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) levels and eventual age-dependent neurodegeneration. The goal of this research was to use Drosophila to understand the etiology of NTE disorders.
AD  - Oregon Health and Science University
AU  - Sunderhaus, Elizabeth
DA  - 2018-05-01
DO  - 10.6083/g4pr-1p73
DO  - DOI
ED  - Kretzschmar, Doris
ED  - Morton, David B.
ED  - Hayflick, Susan
ED  - Logan, Mary
ED  - McCullough, Amanda
ED  - Advisor
ED  - Committee chair
ED  - Committee member
ED  - Committee member
ED  - Committee member
ID  - 3078
KW  - Drosophila
KW  - Drosophila melanogaster
KW  - Hypogonadism
KW  - Neurodegenerative Diseases
KW  - Organophosphates
KW  - Homeostasis
KW  - Cyclic AMP-Dependent Protein Kinases
KW  - neurotoxic esterase
L1  - https://digitalcollections.ohsu.edu/record/3078/files/4011_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/3078/files/4011_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/3078/files/4011_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/3078/files/4011_etd.pdf
N2  - Neuropathy Target Esterase (NTE) is an enzyme localized to the ER that regulates Protein Kinase A (PKA) signaling and maintains lipid homeostasis. Exposure to a  neurotoxic organophosphate or mutations in NTE cause a spectrum of disorders with  neurodegenerative  symptoms  ranging  from  blindness,  hypogonadism, and cerebellar atrophy to motor neuron loss. Understanding how the functions of NTE are  affected by a chemical or  mutations  and  the  mechanisms  of  pathology  is important  for  the identification of pathways  and  development  of  therapeutic   strategies. Loss of NTE’s ortholog, Swiss-Cheese (SWS), in Drosophila  melanogaster causes a dysregulation of PKA signaling, an increase in  phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) levels and eventual age-dependent neurodegeneration. The goal of this research was to use Drosophila to understand the etiology of NTE disorders.
PB  - Oregon Health and Science University
PY  - 2018-05-01
T1  - Identifying the pathogenic mechanisms of swiss-cheese phenotypes to understand neuropathy target esterase associated disorders
TI  - Identifying the pathogenic mechanisms of swiss-cheese phenotypes to understand neuropathy target esterase associated disorders
UR  - https://digitalcollections.ohsu.edu/record/3078/files/4011_etd.pdf
Y1  - 2018-05-01
ER  -