000000309 001__ 309
000000309 005__ 20260423123407.0
000000309 0247_ $$2DOI$$a10.6083/M42F7KD0
000000309 037__ $$aETD
000000309 245__ $$aThe p53 family interacting pathways in carcinogenesis and cellular response to DNA damage
000000309 260__ $$bOregon Health and Science University
000000309 269__ $$a2007
000000309 336__ $$aDissertation
000000309 502__ $$bPh.D.
000000309 502__ $$gMolecular & Medical Genetics (sunsetting)
000000309 520__ $$aThis study investigates the role of p73 in epidermal carcinogenesis and DNA damage responses within the context of p53 family signaling. Loss of p73 promoted malignant conversion of keratinocytes to squamous cell carcinoma and conferred resistance to ionizing radiation, effects reversible by reconstitution of TAp73α but not ΔNp73α. p73 was shown to functionally cooperate with transcriptionally active p63 isoforms to regulate cell cycle arrest and gene expression, while its tumor suppressive role was uncoupled from radiation sensitivity. These findings highlight p73 as a critical regulator of p53 family balance, tumor suppression, and treatment response.
000000309 540__ $$fCC BY
000000309 542__ $$fIn copyright - single owner
000000309 650__ $$aNeoplastic Processes$$022774
000000309 650__ $$aDNA Damage$$017979
000000309 650__ $$aKeratinocytes$$028512
000000309 650__ $$aRadiation$$025066
000000309 650__ $$aDNA-Binding Proteins$$017998
000000309 650__ $$aCarcinogenesis$$040251
000000309 650__ $$aDNA Repair$$017990
000000309 650__ $$aEpithelial Cells$$018550
000000309 650__ $$aTumor Suppressor Protein p53$$028922
000000309 650__ $$aRadiation, Nonionizing$$025079
000000309 650__ $$aUltraviolet Rays$$027554
000000309 650__ $$aRadiation, Ionizing$$025078
000000309 6531_ $$ap63
000000309 6531_ $$ap73
000000309 6531_ $$asquamous cell carcinogenesis
000000309 691__ $$aSchool of Medicine$$041369
000000309 692__ $$aDepartment of Molecular and Medical Genetics$$041428
000000309 7001_ $$aJohnson, Jodi$$uOregon Health and Science University$$041354
000000309 7201_ $$aMartin-Kulesz, Molly$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000309 8564_ $$96bb014d2-6c65-4a9b-aadf-cd756c859f18$$s5349615$$uhttps://digitalcollections.ohsu.edu/record/309/files/309_etd.pdf$$ePublic$$2bbfb9772f2329d7d6296f53db7b40977$$31
000000309 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000309 905__ $$a/rest/prod/1v/53/jw/99/1v53jw99g
000000309 909CO $$ooai:digitalcollections.ohsu.edu:309$$pstudent-work
000000309 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000309 980__ $$aTheses and Dissertations