@article{ETD, recid = {3091}, author = {Edwards, David K.}, title = {Targeting tumor-supportive cells with CSF1R small-molecule inhibitors as a novel treatment strategy for chronic lymphocytic leukemia and acute myeloid leukemia}, publisher = {Oregon Health and Science University}, school = {Ph.D.}, address = {2018-06-01}, number = {ETD}, abstract = {Leukemias comprise a family of hematologic malignancies characterized by the over-proliferation of myeloid precursor cells. Leukemia development depends on multiple factors, including supportive growth signals from non-leukemia cells in the surrounding tumor microenvironment. Identifying these critical supportive cells, and eliminating their support, remains challenging. This dissertation contains novel research that identifies supportive monocyte/macrophage cells expressing colony stimulating factor 1 receptor (CSF1R) in human chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML).}, url = {http://digitalcollections.ohsu.edu/record/3091}, doi = {https://doi.org/10.6083/P0RIUY}, }