TY  - GEN
AB  - Leukemias comprise a family of hematologic malignancies characterized by the over-proliferation of myeloid precursor cells. Leukemia development depends on multiple factors, including supportive growth signals from non-leukemia cells in the surrounding tumor microenvironment. Identifying these critical supportive cells, and eliminating their support, remains challenging. This dissertation contains novel research that identifies supportive monocyte/macrophage cells expressing colony stimulating factor 1 receptor (CSF1R) in human chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML).
AD  - Oregon Health and Science University
AU  - Edwards, David K.
DA  - 2018-06-01
DO  - 10.6083/P0RIUY
DO  - DOI
ED  - Tyner, Jeffrey
ED  - McWeeney, Shannon
ED  - Lind, Evan
ED  - Spellman, Paul
ED  - Weinberg, Andrew
ED  - Kulesz-Martin, Molly
ED  - Courtneidge, Sara
ED  - Mentor
ED  - Co-Mentor
ED  - Committee member
ED  - Committee member
ED  - Committee member
ED  - Advisor
ED  - Committee chair
ID  - 3091
KW  - Macrophage Colony-Stimulating Factor
KW  - Macrophages
KW  - Monocytes
KW  - Cell Proliferation
KW  - Tumor Microenvironment
KW  - Hematologic Neoplasms
KW  - Leukemia, Myeloid, Acute
KW  - Leukemia, Lymphocytic, Chronic, B-Cell
L1  - https://digitalcollections.ohsu.edu/record/3091/files/4046_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/3091/files/4046_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/3091/files/4046_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/3091/files/4046_etd.pdf
N2  - Leukemias comprise a family of hematologic malignancies characterized by the over-proliferation of myeloid precursor cells. Leukemia development depends on multiple factors, including supportive growth signals from non-leukemia cells in the surrounding tumor microenvironment. Identifying these critical supportive cells, and eliminating their support, remains challenging. This dissertation contains novel research that identifies supportive monocyte/macrophage cells expressing colony stimulating factor 1 receptor (CSF1R) in human chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML).
PB  - Oregon Health and Science University
PY  - 2018-06-01
T1  - Targeting tumor-supportive cells with CSF1R small-molecule inhibitors as a novel treatment strategy for chronic lymphocytic leukemia and acute myeloid leukemia
TI  - Targeting tumor-supportive cells with CSF1R small-molecule inhibitors as a novel treatment strategy for chronic lymphocytic leukemia and acute myeloid leukemia
UR  - https://digitalcollections.ohsu.edu/record/3091/files/4046_etd.pdf
Y1  - 2018-06-01
ER  -