TY - GEN AB - Leukemias comprise a family of hematologic malignancies characterized by the over-proliferation of myeloid precursor cells. Leukemia development depends on multiple factors, including supportive growth signals from non-leukemia cells in the surrounding tumor microenvironment. Identifying these critical supportive cells, and eliminating their support, remains challenging. This dissertation contains novel research that identifies supportive monocyte/macrophage cells expressing colony stimulating factor 1 receptor (CSF1R) in human chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). AD - Oregon Health and Science University AU - Edwards, David K. DA - 2018-06-01 DO - 10.6083/P0RIUY DO - DOI ED - Tyner, Jeffrey ED - McWeeney, Shannon ED - Lind, Evan ED - Spellman, Paul ED - Weinberg, Andrew ED - Kulesz-Martin, Molly ED - Courtneidge, Sara ED - Mentor ED - Co-Mentor ED - Committee member ED - Committee member ED - Committee member ED - Advisor ED - Committee chair ID - 3091 KW - Macrophage Colony-Stimulating Factor KW - Macrophages KW - Monocytes KW - Cell Proliferation KW - Tumor Microenvironment KW - Hematologic Neoplasms KW - Leukemia, Myeloid, Acute KW - Leukemia, Lymphocytic, Chronic, B-Cell L1 - https://digitalcollections.ohsu.edu/record/3091/files/4046_etd.pdf L2 - https://digitalcollections.ohsu.edu/record/3091/files/4046_etd.pdf L4 - https://digitalcollections.ohsu.edu/record/3091/files/4046_etd.pdf LK - https://digitalcollections.ohsu.edu/record/3091/files/4046_etd.pdf N2 - Leukemias comprise a family of hematologic malignancies characterized by the over-proliferation of myeloid precursor cells. Leukemia development depends on multiple factors, including supportive growth signals from non-leukemia cells in the surrounding tumor microenvironment. Identifying these critical supportive cells, and eliminating their support, remains challenging. This dissertation contains novel research that identifies supportive monocyte/macrophage cells expressing colony stimulating factor 1 receptor (CSF1R) in human chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). PB - Oregon Health and Science University PY - 2018-06-01 T1 - Targeting tumor-supportive cells with CSF1R small-molecule inhibitors as a novel treatment strategy for chronic lymphocytic leukemia and acute myeloid leukemia TI - Targeting tumor-supportive cells with CSF1R small-molecule inhibitors as a novel treatment strategy for chronic lymphocytic leukemia and acute myeloid leukemia UR - https://digitalcollections.ohsu.edu/record/3091/files/4046_etd.pdf Y1 - 2018-06-01 ER -