000003091 001__ 3091
000003091 005__ 20250424232815.0
000003091 0247_ $$2DOI$$a10.6083/P0RIUY
000003091 037__ $$aETD
000003091 245__ $$aTargeting tumor-supportive cells with CSF1R small-molecule inhibitors as a novel treatment strategy for chronic lymphocytic leukemia and acute myeloid leukemia
000003091 260__ $$bOregon Health and Science University
000003091 269__ $$a2018-06-01
000003091 336__ $$aDissertation
000003091 502__ $$bPh.D.
000003091 520__ $$aLeukemias comprise a family of hematologic malignancies characterized by the over-proliferation of myeloid precursor cells. Leukemia development depends on multiple factors, including supportive growth signals from non-leukemia cells in the surrounding tumor microenvironment. Identifying these critical supportive cells, and eliminating their support, remains challenging. This dissertation contains novel research that identifies supportive monocyte/macrophage cells expressing colony stimulating factor 1 receptor (CSF1R) in human chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML).
000003091 542__ $$fIn copyright - single owner
000003091 650__ $$aMacrophage Colony-Stimulating Factor$$028934
000003091 650__ $$aMacrophages$$021733
000003091 650__ $$aMonocytes$$022414
000003091 650__ $$aCell Proliferation$$036166
000003091 650__ $$aTumor Microenvironment$$039473
000003091 650__ $$aHematologic Neoplasms$$031549
000003091 650__ $$aLeukemia, Myeloid, Acute$$028432
000003091 650__ $$aLeukemia, Lymphocytic, Chronic, B-Cell$$028421
000003091 691__ $$aSchool of Medicine$$041369
000003091 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000003091 7001_ $$aEdwards, David K.$$uOregon Health and Science University$$041354
000003091 7201_ $$aTyner, Jeffrey$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000003091 7201_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354$$7Personal$$eCo-Mentor
000003091 7201_ $$aLind, Evan$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member
000003091 7201_ $$aSpellman, Paul$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member
000003091 7201_ $$aWeinberg, Andrew$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member
000003091 7201_ $$aKulesz-Martin, Molly$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000003091 7201_ $$aCourtneidge, Sara$$uOregon Health and Science University$$041354$$7Personal$$eCommittee chair
000003091 8564_ $$9a13023d4-c3df-4241-b3bc-7a0e68ef9ac3$$s9208922$$uhttps://digitalcollections.ohsu.edu/record/3091/files/4046_etd.pdf$$ePublic$$262f049bc817702f480918050a9d21306$$31
000003091 905__ $$a/rest/prod/bn/99/97/05/bn9997056
000003091 909CO $$ooai:digitalcollections.ohsu.edu:3091$$pstudent-work
000003091 980__ $$aTheses and Dissertations