000003113 001__ 3113
000003113 005__ 20250424232816.0
000003113 0247_ $$2DOI$$a10.6083/BTVR5A
000003113 037__ $$aETD
000003113 245__ $$aStrategies to improve predictions of outcome in glioblastoma multiforme and muscle-invasive bladder cancer
000003113 260__ $$bOregon Health and Science University
000003113 269__ $$a2018-07-01
000003113 336__ $$aDissertation
000003113 502__ $$bPh.D.
000003113 520__ $$aAdvancing precision medicine in the treatment of cancer is complex and requires extensive molecular profiling to identify therapeutic targets and appropriately stratify patients into groups that differ in therapeutic vulnerability. The Cancer Genome Atlas (TCGA) has molecularly defined several cancer types and identified distinct subtypes. However, in some cases identification of molecular subtypes have failed to translate clinically. We hypothesize that more accurate molecular subtyping and patient stratification can be achieved by taking into account intra-tumoral heterogeneity and microenvironment signals.
000003113 542__ $$fIn copyright - single owner
000003113 650__ $$aTumor Microenvironment$$039473
000003113 650__ $$aMolecular Typing$$039386
000003113 650__ $$aUrinary Bladder Neoplasms$$015624
000003113 650__ $$aMuscles$$022535
000003113 650__ $$aPrognosis$$024646
000003113 650__ $$aPrecision Medicine$$038927
000003113 650__ $$aGlioblastoma$$019547
000003113 650__ $$aProportional Hazards Models$$028820
000003113 6531_ $$acox proportional hazards models
000003113 6531_ $$aglioblastoma multiforme
000003113 691__ $$aSchool of Medicine$$041369
000003113 692__ $$aDepartment of Biomedical Engineering$$041397
000003113 7001_ $$aClaunch, Cheryl$$uOregon Health and Science University$$041354
000003113 7201_ $$aGray, Joe W.$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000003113 7201_ $$aKorkola, James E.$$uOregon Health and Science University$$041354$$7Personal$$eCo-mentor
000003113 7201_ $$aSears, Rosalie$$uOregon Health and Science University$$041354$$7Personal$$eCommittee chair
000003113 7201_ $$aLuoh, Shiuh-Wen$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member
000003113 7201_ $$aMuldoon, Leslie L.$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member
000003113 8564_ $$9d8d3a938-314a-4f5c-8775-75b8bc4a729a$$s10091515$$uhttps://digitalcollections.ohsu.edu/record/3113/files/4076_etd.pdf$$ePublic$$23aad72b6fc9894b9de5c629d2cd1add2$$31
000003113 905__ $$a/rest/prod/dz/01/0q/28/dz010q28h
000003113 909CO $$ooai:digitalcollections.ohsu.edu:3113$$pstudent-work
000003113 980__ $$aTheses and Dissertations