@article{ETD, recid = {3127}, author = {Clements, Reena}, title = {Dystroglycan stabilization of basement membranes regulates development of the visual system}, school = {Ph.D.}, address = {2018-03-01}, number = {ETD}, abstract = {During development, specific combinations of molecular cues guide the proper formation of neural circuits. Neuronal migration, axon guidance, and synapse formation and pruning are among the developmental phenomenon that must occur with extreme precision to form a functional nervous system. Due to the complexity of the nervous system and the functional redundancy of many proteins, elucidating the precise nature of the molecular basis of development remains a challenge. n this thesis, I utilize the retina and developing visual system to further elucidate the role of dystroglycan in neuronal development. I utilize genetic models including ISPDL79*/L79* and DGF/-; Six3Cre to answer two questions. First, I examine the role of dystroglycan in the retina, including developmental cell migration, postnatal cellular positioning and laminar targeting of synapses. Second, I investigate how dystroglycan regulates axons as they exit the retina and target retinorecipient brain regions.}, url = {http://digitalcollections.ohsu.edu/record/3127}, doi = {https://doi.org/10.6083/MKG8CE}, }