TY - GEN AB - During development, specific combinations of molecular cues guide the proper formation of neural circuits. Neuronal migration, axon guidance, and synapse formation and pruning are among the developmental phenomenon that must occur with extreme precision to form a functional nervous system. Due to the complexity of the nervous system and the functional redundancy of many proteins, elucidating the precise nature of the molecular basis of development remains a challenge. n this thesis, I utilize the retina and developing visual system to further elucidate the role of dystroglycan in neuronal development. I utilize genetic models including ISPDL79*/L79* and DGF/-; Six3Cre to answer two questions. First, I examine the role of dystroglycan in the retina, including developmental cell migration, postnatal cellular positioning and laminar targeting of synapses. Second, I investigate how dystroglycan regulates axons as they exit the retina and target retinorecipient brain regions. AD - Oregon Health and Science University AU - Clements, Reena DA - 2018-03-01 DO - 10.6083/MKG8CE DO - DOI ED - Barnes, Anthony P. ED - Wright, Kevin ED - Barr-Gillespie, Peter ED - Morgans, Catherine ED - Monk, Kelly ED - Committee chair ED - Advisor ED - Committee member ED - Committee member ED - Committee member ID - 3127 KW - Dystroglycans KW - Retinal Ganglion Cells KW - Retina KW - Embryonic Development KW - Synapses KW - Cell Movement KW - Axon Guidance L1 - https://digitalcollections.ohsu.edu/record/3127/files/4091_etd.pdf L2 - https://digitalcollections.ohsu.edu/record/3127/files/4091_etd.pdf L4 - https://digitalcollections.ohsu.edu/record/3127/files/4091_etd.pdf LK - https://digitalcollections.ohsu.edu/record/3127/files/4091_etd.pdf N2 - During development, specific combinations of molecular cues guide the proper formation of neural circuits. Neuronal migration, axon guidance, and synapse formation and pruning are among the developmental phenomenon that must occur with extreme precision to form a functional nervous system. Due to the complexity of the nervous system and the functional redundancy of many proteins, elucidating the precise nature of the molecular basis of development remains a challenge. n this thesis, I utilize the retina and developing visual system to further elucidate the role of dystroglycan in neuronal development. I utilize genetic models including ISPDL79*/L79* and DGF/-; Six3Cre to answer two questions. First, I examine the role of dystroglycan in the retina, including developmental cell migration, postnatal cellular positioning and laminar targeting of synapses. Second, I investigate how dystroglycan regulates axons as they exit the retina and target retinorecipient brain regions. PY - 2018-03-01 T1 - Dystroglycan stabilization of basement membranes regulates development of the visual system TI - Dystroglycan stabilization of basement membranes regulates development of the visual system UR - https://digitalcollections.ohsu.edu/record/3127/files/4091_etd.pdf Y1 - 2018-03-01 ER -