000003127 001__ 3127 000003127 005__ 20250124174742.0 000003127 0247_ $$2DOI$$a10.6083/MKG8CE 000003127 037__ $$aETD 000003127 245__ $$aDystroglycan stabilization of basement membranes regulates development of the visual system 000003127 269__ $$a2018-03-01 000003127 336__ $$aDissertation 000003127 502__ $$bPh.D. 000003127 502__ $$gNeuroscience 000003127 520__ $$aDuring development, specific combinations of molecular cues guide the proper formation of neural circuits. Neuronal migration, axon guidance, and synapse formation and pruning are among the developmental phenomenon that must occur with extreme precision to form a functional nervous system. Due to the complexity of the nervous system and the functional redundancy of many proteins, elucidating the precise nature of the molecular basis of development remains a challenge. n this thesis, I utilize the retina and developing visual system to further elucidate the role of dystroglycan in neuronal development. I utilize genetic models including ISPDL79*/L79* and DGF/-; Six3Cre to answer two questions. First, I examine the role of dystroglycan in the retina, including developmental cell migration, postnatal cellular positioning and laminar targeting of synapses. Second, I investigate how dystroglycan regulates axons as they exit the retina and target retinorecipient brain regions. 000003127 542__ $$fIn copyright - single owner 000003127 650__ $$aDystroglycans$$036156 000003127 650__ $$aRetinal Ganglion Cells$$025392 000003127 650__ $$aRetina$$025387 000003127 650__ $$aEmbryonic Development$$035917 000003127 650__ $$aSynapses$$026704 000003127 650__ $$aCell Movement$$016289 000003127 650__ $$aAxon Guidance$$011783 000003127 691__ $$aSchool of Medicine$$041369 000003127 692__ $$aVollum Institute$$041509 000003127 7001_ $$aClements, Reena$$uOregon Health and Science University$$041354$$10000-0002-8515-2331 000003127 7201_ $$aBarnes, Anthony P.$$uOregon Health and Science University$$041354$$7Personal$$eCommittee chair 000003127 7201_ $$aWright, Kevin$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor 000003127 7201_ $$aBarr-Gillespie, Peter$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member 000003127 7201_ $$aMorgans, Catherine$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member 000003127 7201_ $$aMonk, Kelly$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member 000003127 8564_ $$9357ca2e9-94e6-45b5-9078-38a549c55914$$s77916509$$uhttps://digitalcollections.ohsu.edu/record/3127/files/4091_etd.pdf 000003127 905__ $$a/rest/prod/37/72/0c/92/37720c92k 000003127 909CO $$ooai:digitalcollections.ohsu.edu:3127$$pstudent-work 000003127 980__ $$aTheses and Dissertations