TY - GEN AB - A defining characteristics of biological signaling is that it is both robust and versatile: the system can respond to a wide variety of inputs and consistently generate outputs specific to each input. This gives the ability for biological systems to adapt to complex environments for optimal fitness. How such robustness and versatility are achieved at once, however, has not been well understood. One effective strategy would be to spatially contain specific signaling modules in specific structures. As such, signaling specificity is ensured by putting specific upstream and downstream components in the same space, and versatility is achieved with the large number of component and structure combinations. AD - Oregon Health and Science University AU - Zhang, Ying DA - 2018-08-01 DO - 10.6083/VJC32M DO - DOI ED - Nan, Xiaolin ED - Barklis, Eric ED - Korkola, James ED - Chang, Young Hwan ED - McCarty, Owen ED - Advisor ED - Committee member ED - Committee member ED - Committee member ED - Committee member ID - 3128 KW - Signal Transduction KW - Adaptation, Physiological KW - Biological Phenomena KW - biological signaling L1 - https://digitalcollections.ohsu.edu/record/3128/files/4092_etd.pdf L2 - https://digitalcollections.ohsu.edu/record/3128/files/4092_etd.pdf L4 - https://digitalcollections.ohsu.edu/record/3128/files/4092_etd.pdf LA - eng LK - https://digitalcollections.ohsu.edu/record/3128/files/4092_etd.pdf N2 - A defining characteristics of biological signaling is that it is both robust and versatile: the system can respond to a wide variety of inputs and consistently generate outputs specific to each input. This gives the ability for biological systems to adapt to complex environments for optimal fitness. How such robustness and versatility are achieved at once, however, has not been well understood. One effective strategy would be to spatially contain specific signaling modules in specific structures. As such, signaling specificity is ensured by putting specific upstream and downstream components in the same space, and versatility is achieved with the large number of component and structure combinations. PB - Oregon Health and Science University PY - 2018-08-01 T1 - Spatial regulation of RAS signaling studied with correlative super-resolution and electron microscopy TI - Spatial regulation of RAS signaling studied with correlative super-resolution and electron microscopy UR - https://digitalcollections.ohsu.edu/record/3128/files/4092_etd.pdf Y1 - 2018-08-01 ER -