000003132 001__ 3132
000003132 005__ 20251009144313.0
000003132 0247_ $$2DOI$$a10.6083/K5WJ1C
000003132 037__ $$aETD
000003132 245__ $$aThe cancer targetome and its application to a pathway perspective on targeted therapy response in acute myeloid leukemia
000003132 260__ $$bOregon Health and Science University
000003132 269__ $$a2018
000003132 336__ $$aDissertation
000003132 502__ $$bPh.D.
000003132 520__ $$bDespite incredible advances in cancer treatment in recent years, precision  oncology faces many ongoing challenges in selecting the best treatment for each  patient. First, we have yet to untangle the mechanisms by which many of our drugs  act, especially with regards to the targets (receptors) to which they bind in the  human body. To this aim we present the Cancer Targetome, which collects drug- target interactions for FDA-approved cancer drugs and proposes an evidence  framework for the supporting  information  accompanying  each  drug-target  interaction.
000003132 540__ $$fCC BY
000003132 542__ $$fIn copyright - single owner
000003132 650__ $$aMedical Oncology$$021943
000003132 650__ $$aNeoplasms$$022758
000003132 6531_ $$acancer
000003132 691__ $$aSchool of Medicine$$041369
000003132 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000003132 7001_ $$aBlucher, Aurora$$uOregon Health and Science University$$041354$$10000-0001-6460-010X
000003132 7201_ $$aWu, Guanming$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000003132 7201_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000003132 8564_ $$9e6d34fea-0ef2-45f3-a7da-64165ed5ffd4$$s5174923$$uhttps://digitalcollections.ohsu.edu/record/3132/files/4096_etd.pdf$$ePublic$$20e1b6a6db34265ca6761a7189588b2a5$$31
000003132 905__ $$a/rest/prod/wm/11/7p/23/wm117p231
000003132 909CO $$ooai:digitalcollections.ohsu.edu:3132$$pstudent-work
000003132 980__ $$aTheses and Dissertations