TY  - THES
AB  - Over  300  million  surgeries  are  performed  worldwide  each  year.  The  ultimate  goal  of  surgery  is  to  repair  damage  or  remove  diseased  tissues,  while  minimizing  comorbidities  by  preserving vital structures such as nerves and blood vessels. However, surgeons still rely mainly  on the basic tools of naked eye visualization and palpation for guidance during surgery, leaving  incomplete  resection  rates  high  and  comorbidities  like  nerve  damage  as  a  major  problem.  Fluorescence-guided  surgery  (FGS)  has  the  potential  to  revolutionize  surgery  by  enhancing  visualization  of  specific  tissues  intraoperatively.  Using  optical  imaging  of  targeted  fluorescent  probes, FGS offers sensitive, real-time, wide-field imaging using compact imaging systems that  are easily integrated into the operating room. Several imaging systems are clinically available for  FGS  applications,  however  only  a  handful  of  contrast  agents  have  been  approved.  Numerous  preclinical  studies  for  new  agents  have  shown  promise  for  improved  surgical  outcomes  such  as  tumor resection  or  nerve-sparing.  However,  as non-curative  diagnostic  agents  these  new  probes  must  overcome  an  enormous  regulatory  challenge  to  achieve  clinical  translation.  The  work  presented herein has been carried out to develop novel targeted contrast agents for tumor margin  detection and nerve identification as well as create more clinically viable administration methods  to  aid  in  their  clinical  translation.
AD  - Oregon Health and Science University
AU  - Barth, Connor
DA  - 2018
DO  - 10.6083/Z4H07L
DO  - DOI
ED  - Gibbs, Summer
ED  - Advisor
ED  - Mentor
ID  - 3135
KW  - Optical Imaging
KW  - Fluorescence
KW  - Optical Imaging
KW  - Nerve sparing
KW  - image guided surgery
L1  - https://digitalcollections.ohsu.edu/record/3135/files/4099_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/3135/files/4099_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/3135/files/4099_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/3135/files/4099_etd.pdf
N2  - Over  300  million  surgeries  are  performed  worldwide  each  year.  The  ultimate  goal  of  surgery  is  to  repair  damage  or  remove  diseased  tissues,  while  minimizing  comorbidities  by  preserving vital structures such as nerves and blood vessels. However, surgeons still rely mainly  on the basic tools of naked eye visualization and palpation for guidance during surgery, leaving  incomplete  resection  rates  high  and  comorbidities  like  nerve  damage  as  a  major  problem.  Fluorescence-guided  surgery  (FGS)  has  the  potential  to  revolutionize  surgery  by  enhancing  visualization  of  specific  tissues  intraoperatively.  Using  optical  imaging  of  targeted  fluorescent  probes, FGS offers sensitive, real-time, wide-field imaging using compact imaging systems that  are easily integrated into the operating room. Several imaging systems are clinically available for  FGS  applications,  however  only  a  handful  of  contrast  agents  have  been  approved.  Numerous  preclinical  studies  for  new  agents  have  shown  promise  for  improved  surgical  outcomes  such  as  tumor resection  or  nerve-sparing.  However,  as non-curative  diagnostic  agents  these  new  probes  must  overcome  an  enormous  regulatory  challenge  to  achieve  clinical  translation.  The  work  presented herein has been carried out to develop novel targeted contrast agents for tumor margin  detection and nerve identification as well as create more clinically viable administration methods  to  aid  in  their  clinical  translation.
PB  - Oregon Health and Science University
PY  - 2018
T1  - Development of tissue-specific fluorescent contrast agents and direct application methods for improved clinical translation of fluorescence-guided surgery
TI  - Development of tissue-specific fluorescent contrast agents and direct application methods for improved clinical translation of fluorescence-guided surgery
UR  - https://digitalcollections.ohsu.edu/record/3135/files/4099_etd.pdf
Y1  - 2018
ER  -