000000323 001__ 323
000000323 005__ 20260420142215.0
000000323 0247_ $$2DOI$$a10.6083/M44747TN
000000323 037__ $$aETD
000000323 245__ $$aDetermining the role of the extended amygdala in regulating alcohol consumption in C57BL/6J mice
000000323 260__ $$bOregon Health and Science University
000000323 269__ $$a2007
000000323 336__ $$aDissertation
000000323 502__ $$bPh.D.
000000323 502__ $$gBehavioral & Systems Neuroscience
000000323 520__ $$aThis dissertation investigated the neural circuitry underlying baseline ethanol consumption and dependence-induced increases in alcohol intake. Focusing on the central extended amygdala (cEA), lesions were performed in the bed nucleus of the stria terminalis (BNSTLP), central nucleus of the amygdala (CeA), and nucleus accumbens (NAc) shell. Results showed these regions contribute to baseline ethanol consumption in limited access paradigms but are not required for the increased intake induced by chronic intermittent ethanol vapor exposure. c-fos analyses identified activation of the NAc shell and core during heightened ethanol consumption. Together, these findings suggest distinct neural mechanisms underlie baseline drinking and dependence-related escalation.
000000323 540__ $$fCC BY
000000323 542__ $$fIn copyright - single owner
000000323 650__ $$aMedicine$$021959
000000323 650__ $$aAlcohol Drinking$$014403
000000323 650__ $$aMice$$036842
000000323 650__ $$aAlcoholism$$014412
000000323 650__ $$aAmygdala$$014642
000000323 650__ $$aEthanol$$014406
000000323 650__ $$aNucleus Accumbens$$023067
000000323 650__ $$aCentral Amygdaloid Nucleus$$040835
000000323 650__ $$aMice$$036842
000000323 6531_ $$ac57bl/6j mice
000000323 6531_ $$aextended amygdala
000000323 6531_ $$aethanol dependence
000000323 6531_ $$ainbred strains
000000323 6531_ $$aethanol consumption
000000323 691__ $$aSchool of Medicine$$041369
000000323 692__ $$aDepartment of Behavioral Neuroscience$$041394
000000323 7001_ $$aDhaher, Ronnie$$uOregon Health and Science University$$041354
000000323 7201_ $$aHitzemann, Bob$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000323 8564_ $$9dfca0281-249b-4041-be94-8dd36b79a693$$s1265775$$uhttps://digitalcollections.ohsu.edu/record/323/files/324_etd.pdf$$ePublic$$287cb82018ea92736178a0fed76518eed$$31
000000323 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000323 905__ $$a/rest/prod/7m/01/bk/71/7m01bk71t
000000323 909CO $$ooai:digitalcollections.ohsu.edu:323$$pstudent-work
000000323 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000323 980__ $$aTheses and Dissertations