000000329 001__ 329
000000329 005__ 20260410124445.0
000000329 0247_ $$2DOI$$a10.6083/M4BR8Q5G
000000329 037__ $$aETD
000000329 245__ $$aConstrained clustering and cognitive decline detection
000000329 260__ $$bOregon Health and Science University
000000329 269__ $$a2008
000000329 336__ $$aDissertation
000000329 502__ $$bPh.D.
000000329 502__ $$gComputer Science &amp; Electrical Engineering (sunsetting)
000000329 520__ $$aThis thesis addresses two topics: constrained clustering and cognitive decline detection. First, we develop probabilistic clustering methods that incorporate pairwise constraints expressing prior beliefs about sample relationships. We introduce Penalized Probabilistic Clustering and a Gaussian process–based approach that more efficiently leverages constraint information. Second, we study detection of cognitive decline from longitudinal clinical data using mixed‑effect models and both generative and discriminative classifiers, including support vector machines with kernels designed for time‑series data. Results demonstrate improved predictive performance, particularly when individual‑specific effects are modeled explicitly.
000000329 540__ $$fCC BY
000000329 542__ $$fIn copyright - single owner
000000329 650__ $$aCognitive Dysfunction$$039814
000000329 650__ $$aCluster Analysis$$028809
000000329 650__ $$aMachine Learning$$011449
000000329 650__ $$aSupervised Machine Learning$$011452
000000329 6531_ $$agaussian process
000000329 6531_ $$atime series classification
000000329 6531_ $$atime-series analysis
000000329 6531_ $$amixed-effect model
000000329 6531_ $$agaussian processes
000000329 6531_ $$amixed effects models (statistics)
000000329 691__ $$aOGI School of Science and Engineering$$041365
000000329 691__ $$aSchool of Medicine$$041369
000000329 7001_ $$aLu, Zhengdong$$uOregon Health and Science University$$041354
000000329 7201_ $$aLeen, Todd$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000329 8564_ $$99d724efa-b251-418f-bfa9-13d00114d9dd$$s4796386$$uhttps://digitalcollections.ohsu.edu/record/329/files/330_etd.pdf$$ePublic$$2749ba904ff355f327ac1e9b5d69c1ed5$$31
000000329 901__ $$a&lt;p&gt;These documents are archival records. They are retained for historical reference only. &lt;/p&gt;&lt;p&gt;&lt;b&gt;Need an accessible version? Use the ‘Get Accessible Copy’ link above.&lt;/b&gt;&lt;/p&gt;
000000329 905__ $$a/rest/prod/wp/98/8j/84/wp988j841
000000329 909CO $$ooai:digitalcollections.ohsu.edu:329$$pstudent-work
000000329 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000329 980__ $$aTheses and Dissertations