000000357 001__ 357
000000357 005__ 20260226153218.0
000000357 0247_ $$2DOI$$a10.6083/M4QV3JHF
000000357 037__ $$aETD
000000357 245__ $$aAugmenting the effector phase of adoptive T cell immunotherapy of cancer
000000357 260__ $$bOregon Health and Science University
000000357 269__ $$a2009
000000357 336__ $$aDissertation
000000357 502__ $$bPh.D.
000000357 520__ $$aAdoptive T cell immunotherapy has shown significant promise in advanced melanoma, with over half of patients who failed standard treatments achieving objective clinical responses after receiving tumor‑specific T cells following nonmyeloablative lymphopenic conditioning. This work examines the T cell populations and molecular mechanisms that enhance anti‑tumor efficacy in this setting. We demonstrate that durable, potent anti‑tumor responses require the presence of both tumor‑specific CD4⁺ and CD8⁺ T cells in the lymphopenic host. Additionally, we show that T cells deficient in the ubiquitin‑specific protease Ubp43 exhibit superior therapeutic activity compared to wild‑type cells. These findings highlight key cellular components essential for effective adoptive T cell therapy and suggest a strategy to improve clinical outcomes by targeting Ubp43.
000000357 540__ $$fCC BY
000000357 542__ $$fIn copyright - single owner
000000357 650__ $$aImmune System$$020666
000000357 650__ $$aImmunotherapy$$020724
000000357 650__ $$aNeoplasms$$022758
000000357 650__ $$aCD8-Positive T-Lymphocytes$$030782
000000357 650__ $$aAdoptive Transfer$$031483
000000357 650__ $$aMelanoma$$021989
000000357 691__ $$aSchool of Medicine$$041369
000000357 692__ $$aDepartment of Molecular and Medical Genetics$$041428
000000357 7001_ $$aFriedman, Kevin$$uOregon Health and Science University$$041354
000000357 7201_ $$aFox, Bernard$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000357 8564_ $$9fcc61c66-0cc3-4fff-87e6-656835ba8435$$s1247138$$uhttps://digitalcollections.ohsu.edu/record/357/files/358_etd.pdf$$ePublic$$20f16998530c1ad39ee858b4b0cf002a4$$31
000000357 905__ $$a/rest/prod/5d/86/p0/22/5d86p0224
000000357 909CO $$ooai:digitalcollections.ohsu.edu:357$$pstudent-work
000000357 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000357 980__ $$aTheses and Dissertations