000000366 001__ 366
000000366 005__ 20260410124446.0
000000366 0247_ $$2DOI$$a10.6083/M4K35RM6
000000366 037__ $$aETD
000000366 245__ $$aGene regulation of the shipworm symbiont, Teredinibacter turnerae strain T7901
000000366 260__ $$bOregon Health and Science University
000000366 269__ $$a2010
000000366 336__ $$aThesis
000000366 502__ $$bM.S.
000000366 520__ $$aNatural products remain a critical source of new therapeutics, and the emergence of novel diseases highlights the need for new drug classes. Teredinibacter turnerae T7901, a bacterial symbiont of shipworms, dedicates a large portion of its genome to secondary metabolite biosynthesis and the production of enzymes for wood degradation. This study used microarray and qRT‑PCR analyses to characterize the regulatory systems controlling these secondary metabolite and carbohydrate‑active gene clusters. Bioassays identified antimicrobial activities linked to phosphate‑ and iron‑regulated pathways, and protein analyses revealed components of siderophore uptake. Results support the symbiont’s dual role in nutrient acquisition and chemical defense, and establish optimized conditions for future discovery of bioactive metabolites and cellulolytic enzymes with biotechnological potential.
000000366 540__ $$fCC BY
000000366 542__ $$fIn copyright - single owner
000000366 650__ $$aGene Expression Regulation$$019437
000000366 650__ $$aGene Expression$$028717
000000366 650__ $$aSymbiosis$$026695
000000366 650__ $$aBiological Products$$015564
000000366 650__ $$aTeredinibacter turnerae
000000366 6531_ $$anatual product
000000366 6531_ $$ashipworm
000000366 6531_ $$ametabolites
000000366 691__ $$aSchool of Medicine$$041369
000000366 692__ $$aDepartment of Science and Engineering$$041447
000000366 7001_ $$aFishman, Brian$$uOregon Health and Science University$$041354
000000366 7201_ $$aHaygood, Margo$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000366 8564_ $$9550868b7-56a8-4a30-821b-37a1eedecd50$$s9082563$$uhttps://digitalcollections.ohsu.edu/record/366/files/367_etd.pdf$$ePublic$$2f4cb3a8034ecf868c1ebfa39a9d5bd49$$31
000000366 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000366 905__ $$a/rest/prod/80/49/g5/05/8049g505r
000000366 909CO $$ooai:digitalcollections.ohsu.edu:366$$pstudent-work
000000366 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000366 980__ $$aTheses and Dissertations