000000367 001__ 367
000000367 005__ 20260220090419.0
000000367 0247_ $$2DOI$$a10.6083/M4FB50WV
000000367 037__ $$aETD
000000367 245__ $$aPhysiologically based computational modeling of the hypothalamic-pituitary-gonadal axis in fathead minnows
000000367 260__ $$bOregon Health and Science University
000000367 269__ $$a2010
000000367 336__ $$aDissertation
000000367 502__ $$bPh.D.
000000367 520__ $$aEndocrine‑disrupting chemicals (EDCs) interfere with reproduction in fish by altering signals in the hypothalamic‑pituitary‑gonadal (HPG) axis. This dissertation examines the effects of estrogenic EDCs, including natural 17β‑estradiol (E2) and synthetic 17α‑ethynylestradiol (EE2), as well as the androgenic compound 17β‑trenbolone (TB), on male and female fathead minnows. Physiologically based computational models of the HPG axis were developed for unexposed and exposed fish and calibrated using experimental data. Model predictions aligned well with observed reproductive endpoints, demonstrating robust performance. A third model linking vitellogenin uptake to oocyte growth further connected biochemical disruption to reproductive outcomes. Together, these models provide tools for predicting reproductive effects of EDCs and support regulatory evaluation and monitoring efforts.
000000367 540__ $$fCC BY
000000367 542__ $$fIn copyright - single owner
000000367 650__ $$aEndocrine Disruptors$$037143
000000367 650__ $$aHormones$$020304
000000367 650__ $$aCyprinidae$$017296
000000367 650__ $$aEcotoxicology$$038010
000000367 650__ $$aModels, Theoretical$$022380
000000367 650__ $$aComputer Simulation$$016989
000000367 650__ $$aHypothalamic-Pituitary-Gonadal Axis$$013990
000000367 650__ $$aHormones, Hormone Substitutes, and Hormone Antagonists$$020306
000000367 6531_ $$afathead minnow
000000367 6531_ $$acomputational modeling
000000367 691__ $$aSchool of Medicine$$041369
000000367 692__ $$aDepartment of Science and Engineering$$041447
000000367 7001_ $$aLi, Zhenhong$$uOregon Health and Science University$$041354
000000367 7201_ $$aWatanabe, Karen$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000367 8564_ $$9223115ca-a3b8-4b1a-a466-8acb7166bf10$$s2972548$$uhttps://digitalcollections.ohsu.edu/record/367/files/368_etd.pdf$$ePublic$$2e9cfa0f21f75a3b13cabc0787af96a51$$31
000000367 905__ $$a/rest/prod/jm/21/4p/17/jm214p174
000000367 909CO $$ooai:digitalcollections.ohsu.edu:367$$pstudent-work
000000367 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000367 980__ $$aTheses and Dissertations