000000370 001__ 370 000000370 005__ 20250515154340.0 000000370 0247_ $$2DOI$$a10.6083/M4251G5K 000000370 037__ $$aETD 000000370 245__ $$aVasopressin therapy does not improve return of spontaneous circulation in out-of-hospital cardiac arrest 000000370 269__ $$a2008 000000370 336__ $$aThesis 000000370 502__ $$bM.P.H. 000000370 520__ $$aVasopressin improves peripheral vascular resistance and volume retention without increasing myocardial oxygen demand, offering a potential advantage over epinephrine for cardiac arrest treatment. While early trials showed promise, larger randomized studies did not confirm a general benefit. However, one notable study indicated that patients with asystole might benefit from vasopressin therapy. Our analysis uses data from a large urban EMS system that implemented vasopressin for asystole in January 2005. We compare the rate of return of spontaneous circulation (ROSC) in patients treated before and after this protocol change. 000000370 540__ $$fCC BY 000000370 542__ $$fIn copyright - single owner 000000370 650__ $$aDrug Therapy$$018086 000000370 650__ $$aVasopressins$$027746 000000370 650__ $$aHeart Arrest$$019929 000000370 650__ $$aReturn of Spontaneous Circulation$$013390 000000370 650__ $$aDrug-Related Side Effects and Adverse Reactions$$040408 000000370 691__ $$aSchool of Medicine$$041369 000000370 692__ $$aDepartment of Public Health and Preventive Medicine$$041444 000000370 7001_ $$aHoskins, Greg$$uOregon Health and Science University$$041354 000000370 7201_ $$aLambert, William$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor 000000370 7201_ $$aFu, Rochelle$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member 000000370 7201_ $$aNewgard, Craig$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member 000000370 8564_ $$9d766d713-cce4-49d4-b797-885ae1fab5f7$$s90883$$uhttps://digitalcollections.ohsu.edu/record/370/files/371_etd.pdf$$ePublic$$2b663f131e06eef7022cac1d689ab5eb2$$31 000000370 905__ $$a/rest/prod/nc/58/0m/66/nc580m66v 000000370 909CO $$ooai:digitalcollections.ohsu.edu:370$$pstudent-work 000000370 980__ $$aTheses and Dissertations