000000380 001__ 380
000000380 005__ 20260421131035.0
000000380 0247_ $$2DOI$$a10.6083/M4RN35T5
000000380 037__ $$aETD
000000380 245__ $$aImmunological basis of age-related vulnerability to viral infection
000000380 260__ $$bOregon Health and Science University
000000380 269__ $$a2007
000000380 336__ $$aThesis
000000380 502__ $$bPh.D.
000000380 502__ $$gMolecular Microbiology & Immunology (sunsetting)
000000380 520__ $$aWest Nile virus (WNV) is an emerging arbovirus that disproportionately causes severe neurological disease in elderly individuals. This dissertation describes the development of a novel aged-mouse model of WNV infection to investigate age-related factors contributing to increased disease susceptibility. Using this model, we demonstrate that aged mice exhibit enhanced susceptibility to WNV encephalitis associated with defects in antigen-specific T cell responses, including impaired production of interferon-γ and granzyme B. We further identify WNV-specific CD4 and CD8 T cell epitopes and characterize functional T cell responses in C57BL/6 mice. These findings advance understanding of immune senescence in WNV infection and support the development of targeted vaccines and therapeutics for the elderly.
000000380 540__ $$fCC BY
000000380 542__ $$fIn copyright - single owner
000000380 650__ $$aVaccinia$$027695
000000380 650__ $$aWest Nile Virus Vaccines$$037264
000000380 650__ $$aWest Nile virus$$027964
000000380 650__ $$aVaccines$$027692
000000380 650__ $$aT-Lymphocytes$$026731
000000380 650__ $$aDisease Susceptibility$$017935
000000380 650__ $$aArboviruses$$015034
000000380 650__ $$aAged$$014351
000000380 650__ $$aMice$$036842
000000380 650__ $$aAllergy and Immunology$$014456
000000380 691__ $$aSchool of Medicine$$041369
000000380 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000380 7001_ $$aBrien, James$$uOregon Health and Science University$$041354
000000380 7201_ $$aNikolich, Janko$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000380 8564_ $$94c46a3a7-39a2-4d67-95f8-7f1c46b62091$$s55013831$$uhttps://digitalcollections.ohsu.edu/record/380/files/381_etd.pdf$$ePublic$$20cbd6244ebf1969e7650ed804f4b9942$$31
000000380 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000380 905__ $$a/rest/prod/g7/32/d8/98/g732d898n
000000380 909CO $$ooai:digitalcollections.ohsu.edu:380$$pstudent-work
000000380 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000380 980__ $$aTheses and Dissertations