000000383 001__ 383
000000383 005__ 20260305080846.0
000000383 0247_ $$2DOI$$a10.6083/M4CF9N2W
000000383 037__ $$aETD
000000383 245__ $$aThe role of virally encoded chemokines and chemokine inhibitors in health and disease
000000383 260__ $$bOregon Health and Science University
000000383 269__ $$a2008
000000383 336__ $$aDissertation
000000383 502__ $$bPh.D.
000000383 520__ $$aChemokines regulate immune cell migration and play essential roles in development, angiogenesis, and hematopoiesis. Several viruses exploit this system by encoding chemokine mimics or inhibitors to enhance infection and immune evasion. This dissertation examines two such viral proteins. First, we show that rhesus rhadinovirus (RRV) encodes a functional chemokine homolog, vMIP, which induces migration of THP‑1 cells in vitro and recruits CD14⁺ cells in vivo. Because CD14⁺ cells are permissive to RRV, vMIP may promote viral dissemination. Second, we characterize the monkeypox virus chemokine inhibitor vCCI, demonstrating that it binds rhesus MIP‑1α, blocks chemotaxis in vitro, reduces CD14⁺ recruitment in vivo, and suppresses both acute and relapsing phases of experimental allergic encephalomyelitis. These findings highlight opposing viral strategies of chemokine mimicry and inhibition and identify vCCI as a potential therapeutic agent for chemokine‑driven inflammatory diseases.
000000383 540__ $$fCC BY
000000383 542__ $$fIn copyright - single owner
000000383 650__ $$aChemokines$$031204
000000383 650__ $$aPoxviridae$$024490
000000383 650__ $$aMultiple Sclerosis$$022506
000000383 650__ $$aChemotaxis$$016449
000000383 650__ $$aRhadinovirus$$030543
000000383 650__ $$aEncephalomyelitis, Autoimmune, Experimental$$018394
000000383 650__ $$aHerpesvirus 1, Cercopithecine$$020162
000000383 650__ $$aAllergy and Immunology$$014456
000000383 650__ $$aLeukocytes$$021450
000000383 650__ $$aHumans
000000383 691__ $$aSchool of Medicine$$041369
000000383 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000383 7001_ $$aJones, John$$uOregon Health and Science University$$041354
000000383 7201_ $$aWong, Scott$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000383 8564_ $$9d5897919-6bcb-4e4c-82be-8af4e4cbead4$$s1461531$$uhttps://digitalcollections.ohsu.edu/record/383/files/384_etd.pdf$$ePublic$$2d65e6965ef4cfda2e123b380c891c6fe$$31
000000383 905__ $$a/rest/prod/bg/25/7f/06/bg257f06r
000000383 909CO $$ooai:digitalcollections.ohsu.edu:383$$pstudent-work
000000383 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000383 980__ $$aTheses and Dissertations