TY  - GEN
AB  - Cartwheel cells in the dorsal cochlear nucleus are glycinergic interneurons whose complex spike activity influences principal neuron responses. Using gramicidin perforated‑patch recordings in mouse brain slices, this study examined the ionic basis of complex spikes and regulation of the glycine reversal potential (Egly_\text{gly}gly​). Complex spikes required both sodium and calcium currents, with specific calcium channel types shaping the slow depolarization and calcium‑activated potassium channels regulating repolarization. Complex spiking also produced calcium‑dependent intracellular acidification, leading to a negative shift in Egly_\text{gly}gly​ through activation of the Na+^++-driven Cl−^-−/HCO3−_3^-3−​ exchanger. This shift likely provides feedback inhibition to limit excessive spiking.
AD  - Oregon Health and Science University
AU  - Kim, Yuil
DA  - 2009
DO  - 10.6083/M4QN64PS
DO  - DOI
ED  - Trussell, Laurence
ED  - Mentor
ID  - 388
KW  - Action Potentials
KW  - Calcium Channels
KW  - Physiology
KW  - Cochlear Nucleus
KW  - Chlorides
L1  - https://digitalcollections.ohsu.edu/record/388/files/389_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/388/files/389_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/388/files/389_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/388/files/389_etd.pdf
N2  - Cartwheel cells in the dorsal cochlear nucleus are glycinergic interneurons whose complex spike activity influences principal neuron responses. Using gramicidin perforated‑patch recordings in mouse brain slices, this study examined the ionic basis of complex spikes and regulation of the glycine reversal potential (Egly_\text{gly}gly​). Complex spikes required both sodium and calcium currents, with specific calcium channel types shaping the slow depolarization and calcium‑activated potassium channels regulating repolarization. Complex spiking also produced calcium‑dependent intracellular acidification, leading to a negative shift in Egly_\text{gly}gly​ through activation of the Na+^++-driven Cl−^-−/HCO3−_3^-3−​ exchanger. This shift likely provides feedback inhibition to limit excessive spiking.
PB  - Oregon Health and Science University
PY  - 2009
T1  - Studies on the electrical properties of the dorsal cochlear nucleus cartwheel neurons
TI  - Studies on the electrical properties of the dorsal cochlear nucleus cartwheel neurons
UR  - https://digitalcollections.ohsu.edu/record/388/files/389_etd.pdf
Y1  - 2009
ER  -