000000388 001__ 388
000000388 005__ 20260303150351.0
000000388 0247_ $$2DOI$$a10.6083/M4QN64PS
000000388 037__ $$aETD
000000388 245__ $$aStudies on the electrical properties of the dorsal cochlear nucleus cartwheel neurons
000000388 260__ $$bOregon Health and Science University
000000388 269__ $$a2009
000000388 336__ $$aDissertation
000000388 502__ $$bPh.D.
000000388 502__ $$gNeuroscience
000000388 520__ $$aCartwheel cells in the dorsal cochlear nucleus are glycinergic interneurons whose complex spike activity influences principal neuron responses. Using gramicidin perforated‑patch recordings in mouse brain slices, this study examined the ionic basis of complex spikes and regulation of the glycine reversal potential (Egly_\text{gly}gly​). Complex spikes required both sodium and calcium currents, with specific calcium channel types shaping the slow depolarization and calcium‑activated potassium channels regulating repolarization. Complex spiking also produced calcium‑dependent intracellular acidification, leading to a negative shift in Egly_\text{gly}gly​ through activation of the Na+^++-driven Cl−^-−/HCO3−_3^-3−​ exchanger. This shift likely provides feedback inhibition to limit excessive spiking.
000000388 540__ $$fCC BY
000000388 542__ $$fIn copyright - single owner
000000388 650__ $$aAction Potentials$$014197
000000388 650__ $$aCalcium Channels$$028229
000000388 650__ $$aPhysiology$$024123
000000388 650__ $$aCochlear Nucleus$$030119
000000388 650__ $$aChlorides$$016523
000000388 691__ $$aSchool of Medicine$$041369
000000388 692__ $$aVollum Institute$$041509
000000388 7001_ $$aKim, Yuil$$uOregon Health and Science University$$041354
000000388 7201_ $$aTrussell, Laurence$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000388 8564_ $$91a36de3a-2d46-4b91-b745-5afa3453e523$$s15940101$$uhttps://digitalcollections.ohsu.edu/record/388/files/389_etd.pdf$$ePublic$$2c9014f7db6276e5c0f781a7664fb451d$$31
000000388 905__ $$a/rest/prod/sb/39/78/29/sb397829v
000000388 909CO $$ooai:digitalcollections.ohsu.edu:388$$pstudent-work
000000388 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000388 980__ $$aTheses and Dissertations