000000390 001__ 390
000000390 005__ 20260220082318.0
000000390 0247_ $$2DOI$$a10.6083/M4G73BNC
000000390 037__ $$aETD
000000390 245__ $$ap75 neurotrophin receptor modulates the development and post-infarct remodeling of cardiac sympathetic neurons
000000390 260__ $$bOregon Health and Science University
000000390 269__ $$a2010
000000390 336__ $$aDissertation
000000390 502__ $$bPh.D.
000000390 520__ $$aMyocardial infarction (MI) affects more than one million Americans each year, and survivors face a high risk of ventricular arrhythmias and sudden cardiac death. Abnormal remodeling of the sympathetic nervous system, characterized by regions of hyperinnervation and denervation in the viable myocardium, contributes to this vulnerability. While excess nerve growth factor explains post MI hyperinnervation, the cause of sympathetic denervation remains unclear. Recent evidence shows that activation of the p75 neurotrophin receptor (p75NTR) by brain derived neurotrophic factor (BDNF) triggers sympathetic axon degeneration. Because BDNF is transiently upregulated after MI, I hypothesized that p75NTR mediated signaling drives sympathetic denervation following myocardial infarction.
000000390 540__ $$fCC BY
000000390 542__ $$fIn copyright - single owner
000000390 650__ $$aNerve Growth Factor$$032821
000000390 650__ $$aMyocardial Infarction$$022601
000000390 650__ $$aAutonomic Nervous System$$015250
000000390 650__ $$aDeath, Sudden, Cardiac$$029385
000000390 650__ $$aSympathetic Nervous System$$026699
000000390 650__ $$aBrain-Derived Neurotrophic Factor$$031432
000000390 650__ $$aReceptor, Nerve Growth Factor$$032709
000000390 650__ $$aArrhythmias, Cardiac$$015069
000000390 691__ $$aSchool of Medicine$$041369
000000390 692__ $$aDepartment of Physiology and Pharmacology$$041442
000000390 7001_ $$aLorentz, Christina$$uOregon Health and Science University$$041354
000000390 7201_ $$aHabecker, Beth$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000390 8564_ $$9bb6cacd5-17bb-46b7-a008-99f35c1ccc63$$s4238771$$uhttps://digitalcollections.ohsu.edu/record/390/files/391_etd.pdf$$ePublic$$22a5fb49bd422fdc873668e89482938d6$$31
000000390 905__ $$a/rest/prod/3j/33/32/25/3j333225q
000000390 909CO $$ooai:digitalcollections.ohsu.edu:390$$pstudent-work
000000390 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000390 980__ $$aTheses and Dissertations