000041286 001__ 41286
000041286 005__ 20240125142349.0
000041286 0247_ $$2doi$$a10.6083/bpxhc41286
000041286 037__ $$aIR
000041286 041__ $$aeng
000041286 245__ $$aSpirometry in a longitudinal pediatric population pre- and post COVID-19 infection
000041286 260__ $$bOregon Health and Science University
000041286 269__ $$a2023-07-18
000041286 336__ $$aAbstract
000041286 520__ $$aAs of December 2022, over 15 million children have tested positive for COVID-19. Little is known about how this novel virus may impact long term health outcomes in children, particularly respiratory health of children exposed to in-utero and postnatal cigarette smoke. At this time there is no literature on spirometry pre and post COVID-19 infection in a pediatric population. To compare forced expiratory flows (FEFs) pre and post COVID-19 infection in a longitudinal cohort of children born to pregnant smokers. The occurrence of wheeze was also compared. We identified children with a diagnosis of COVID-19 between 2/2020 to 9/2022 from a cohort of 213 children (age 5-8 years) being followed longitudinally from a randomized controlled trial (RCT) of vitamin C supplementation versus placebo to pregnant smokers. These children are studied with yearly spirometry. Inclusion criteria: 1) Offspring of a pregnant smoker randomized in the above RCT; 2) Parent reported Yes to, “Has a healthcare provider ever told you that your child had, or likely had, COVID-19?” or a confirmed positive COVID-19 test via nasal swab; 3) Spirometry completed within one year pre- and post COVID-19 infection. The primary outcome was the comparison of FEFs (specifically FEF25-75 [FEF between 25% and 75% expired volume]) pre- and post COVID-19 infection. The occurrence of wheeze in the 1 year pre- and post COVID-19 diagnosis (yes versus no) was also compared. 36 children met the inclusion criteria (64% white non-Hispanic; 47% male; 69% living with a smoking primary caregiver at the time of the pre-COVID spirometry). Median age at COVID-19 infection was 7.0 years (range 5.4-8.8 years). None of the children required hospitalization. There was no significant difference between the pre- and post- spirometry data (Table 1) after adjustment for sex, race, height, and age at testing. Four children had wheeze in the year prior to infection, compared to 11 in the year post COVID-19 infection. The results in this subset of patients from an ongoing longitudinal cohort show no difference in spirometry/ FEF25-75 in children born to pregnant smokers when tested within one-year pre and post COVID-19 infection.
000041286 540__ $$fCC BY
000041286 542__ $$fIn copyright - joint owners
000041286 650__ $$aPublic Health$$024885
000041286 650__ $$aCOVID-19$$013515
000041286 650__ $$aSpirometry$$026308
000041286 650__ $$aPregnancy Complications$$024524
000041286 650__ $$aSmoking$$026083
000041286 650__ $$aPrenatal Exposure Delayed Effects$$024568
000041286 650__ $$aSubstance-Related Disorders$$032029
000041286 650__ $$aMaternal Behavior$$021875
000041286 650__ $$aCigarette Smoking$$012213
000041286 6531_ $$awheeze
000041286 6531_ $$aheart, lung, & blood
000041286 6531_ $$acovid-19 complications
000041286 692__ $$aDoernbecher Children's Hospital$$041469
000041286 7001_ $$aHarris, Julia$$uOregon Health and Science University$$041354
000041286 7001_ $$aMartin, Alec$$uOregon Health and Science University$$041354
000041286 7001_ $$aMilner, Kristin$$uOregon Health and Science University$$041354
000041286 7001_ $$aTiller, Christina$$uIndiana University
000041286 7001_ $$aBrownsberger, Julie$$uOregon Health and Science University$$041354
000041286 7001_ $$aVuylsteke, Brittany$$uOregon Health and Science University$$041354
000041286 7001_ $$aPetrey, Anna$$uOregon Health and Science University$$041354
000041286 7001_ $$aMazziotti, Julianna$$uOregon Health and Science University$$041354
000041286 7001_ $$aRabe, Katy$$uOregon Health and Science University$$041354
000041286 7001_ $$aPark, Byung$$uOregon Health and Science University$$041354
000041286 7001_ $$aTepper, Robert$$uIndiana University
000041286 7001_ $$aMcEvoy, Cindy$$uOregon Health and Science University$$041354
000041286 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000041286 7201_ $$aMcEvoy, Cindy$$7Personal
000041286 8564_ $$9b339338d-681d-434b-885e-3dfc8be377b9$$s392391$$uhttps://digitalcollections.ohsu.edu/record/41286/files/ResearchWeek.2023.Harris.Julia.pdf
000041286 980__ $$aResearch Week
000041286 981__ $$aPublished$$b2023-07-18