000041292 001__ 41292
000041292 005__ 20240408153137.0
000041292 0247_ $$2doi$$a10.6083/bpxhc41292
000041292 037__ $$aIR
000041292 041__ $$aeng
000041292 245__ $$aHigher prenatal dietary glycemic index predicts greater subjective and objective negative affect in six-month-old infants: a prospective longitudinal study
000041292 260__ $$bOregon Health and Science University
000041292 269__ $$a2023-07-19
000041292 336__ $$aAbstract
000041292 520__ $$aThe dietary glycemic index (GI) reflects the rate of post-prandial plasma glucose generation, with higher GI foods rapidly increasing blood sugar. Consumption of high-GI foods during pregnancy has been linked to offspring risk for obesity and metabolic disorders, but the independent effects of high dietary GI on infant neurodevelopment have not been clarified in the context of birthing parent metabolic health. We examined the relationship of birthing parent dietary GI, insulin resistance, and adiposity during pregnancy on infant negative affect, an early marker of neurodevelopmental risk. Subjects were 302 birthing parent-infant dyads. Assessments during the second and third trimesters included: birthing parent dietary quality (three 24-hour dietary recalls/trimester), adiposity (air displacement plethysmography), and insulin sensitivity (the homeostatic model assessment for insulin resistance (HOMA-IR) was calculated from fasting plasma glucose and insulin concentrations). At six months old, infant temperament was evaluated using subjective (Infant Behavior Questionnaire-Revised) and objective measures (Still Face paradigm). Auxiliary variables, including birthing parent race, ethnicity, parity, and age, were self-reported and mood was captured using the Center for Epidemiological Studies Depression Scale. Structural equation models accounting for the interdependence of dietary GI, adiposity, and insulin sensitivity during each trimester, and adjusted for covariates, showed that higher HOMA-IR values in the second, but not the third trimester, predicted higher objective infant negative affect at six months (β = .237, p = .0001). Conversely, higher dietary GI during the third, but not the second, trimester predicted higher subjective (β = .121, p = .040) and objective infant negative affect (β = .121, p = .043). These results suggest that birthing parent insulin sensitivity and dietary quality may be important targets for improving infant neurodevelopment. Given its modifiable nature, interventions with a particular focus on reducing high GI food intake during the later stages of pregnancy may be most effective.
000041292 540__ $$fCC BY
000041292 542__ $$fIn copyright - joint owners
000041292 650__ $$aNutritional Sciences$$037227
000041292 650__ $$aGlycemic Control$$013452
000041292 650__ $$aChild Nutrition Sciences$$037299
000041292 650__ $$aTemperament$$026817
000041292 650__ $$aGlycemic Index$$034887
000041292 650__ $$aPregnancy$$024523
000041292 6531_ $$aearly childhood development
000041292 6531_ $$adevelopmental programming
000041292 6531_ $$aprenatal diet
000041292 691__ $$aSchool of Medicine$$041369
000041292 692__ $$aDepartment of Psychiatry$$041443
000041292 7001_ $$aWood, Elizabeth$$uOregon Health and Science University$$041354
000041292 7001_ $$aGustafsson, Hanna$$uOregon Health and Science University$$041354
000041292 7001_ $$aNigg, Joel$$uOregon Health and Science University$$041354
000041292 7001_ $$aSullivan, Elinor$$uOregon Health and Science University$$041354
000041292 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000041292 7201_ $$7Personal
000041292 8564_ $$9ed641041-c040-4893-a2ba-6b570e61777f$$s177149$$uhttps://digitalcollections.ohsu.edu/record/41292/files/ResearchWeek.2023.Wood.Elizabeth.pdf
000041292 981__ $$aPublished$$b2023-07-19