TY  - GEN
AB  - Lipopolysaccharide (LPS), the major outer wall component of Gram-negative bacteria, plays a critical role in the pathogenesis of sepsis and are known to contribute to the development of disseminated intravascular coagulation (DIC) syndrome. Since LPS aggregates are negatively charged, we hypothesized that LPS may directly interact with and activate the contact pathway coagulation factor (F) XII as part of the pathogenesis of DIC. This project aims to investigate the mechanisms of interaction and activation of FXII by LPS chemotypes.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Lira Da Silva, Andre
AU  - Aslan, Joseph E.
AU  - McCarty, Owen J.
DA  - 2023-07-20
DO  - 10.6083/bpxhc41305
DO  - doi
ED  - Puy, Cristina
ED  - Collaborator
ID  - 41305
KW  - Biochemistry
KW  - Biophysics
KW  - Factor XII
KW  - Bacteria
KW  - Lipopolysaccharides
KW  - Blood Coagulation
KW  - Factor XII
KW  - hageman factor
KW  - blood clotting
KW  - lipopolysaccharide chemotypes
L1  - https://digitalcollections.ohsu.edu/record/41305/files/ResearchWeek.2023.LiradaSilva.Andre.pdf
L2  - https://digitalcollections.ohsu.edu/record/41305/files/ResearchWeek.2023.LiradaSilva.Andre.pdf
L4  - https://digitalcollections.ohsu.edu/record/41305/files/ResearchWeek.2023.LiradaSilva.Andre.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/41305/files/ResearchWeek.2023.LiradaSilva.Andre.pdf
N2  - Lipopolysaccharide (LPS), the major outer wall component of Gram-negative bacteria, plays a critical role in the pathogenesis of sepsis and are known to contribute to the development of disseminated intravascular coagulation (DIC) syndrome. Since LPS aggregates are negatively charged, we hypothesized that LPS may directly interact with and activate the contact pathway coagulation factor (F) XII as part of the pathogenesis of DIC. This project aims to investigate the mechanisms of interaction and activation of FXII by LPS chemotypes.
PB  - Oregon Health and Science University
PY  - 2023-07-20
T1  - Effects of bacteria lipopolysaccharides on the activation and activity of coagulation factor XII
TI  - Effects of bacteria lipopolysaccharides on the activation and activity of coagulation factor XII
UR  - https://digitalcollections.ohsu.edu/record/41305/files/ResearchWeek.2023.LiradaSilva.Andre.pdf
Y1  - 2023-07-20
ER  -