000041305 001__ 41305
000041305 005__ 20240405105441.0
000041305 0247_ $$2doi$$a10.6083/bpxhc41305
000041305 037__ $$aIR
000041305 041__ $$aeng
000041305 245__ $$aEffects of bacteria lipopolysaccharides on the activation and activity of coagulation factor XII
000041305 260__ $$bOregon Health and Science University
000041305 269__ $$a2023-07-20
000041305 336__ $$aAbstract
000041305 520__ $$aLipopolysaccharide (LPS), the major outer wall component of Gram-negative bacteria, plays a critical role in the pathogenesis of sepsis and are known to contribute to the development of disseminated intravascular coagulation (DIC) syndrome. Since LPS aggregates are negatively charged, we hypothesized that LPS may directly interact with and activate the contact pathway coagulation factor (F) XII as part of the pathogenesis of DIC. This project aims to investigate the mechanisms of interaction and activation of FXII by LPS chemotypes.
000041305 540__ $$fCC BY
000041305 542__ $$fIn copyright - joint owners
000041305 650__ $$aBiochemistry$$015549
000041305 650__ $$aBiophysics$$015579
000041305 650__ $$aFactor XII$$018861
000041305 650__ $$aBacteria$$015323
000041305 650__ $$aLipopolysaccharides$$021552
000041305 650__ $$aBlood Coagulation$$015652
000041305 650__ $$aFactor XII$$018861
000041305 6531_ $$ahageman factor
000041305 6531_ $$ablood clotting
000041305 6531_ $$alipopolysaccharide chemotypes
000041305 691__ $$aSchool of Medicine$$041369
000041305 692__ $$aDepartment of Biomedical Engineering$$041397
000041305 7001_ $$aLira Da Silva, Andre$$uOregon Health and Science University$$041354
000041305 7001_ $$aAslan, Joseph E.$$uOregon Health and Science University$$041354
000041305 7001_ $$aMcCarty, Owen J.$$uOregon Health and Science University$$041354
000041305 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000041305 7201_ $$aPuy, Cristina$$uOregon Health & Science University$$eCollaborator$$7Personal
000041305 8564_ $$9bf6aabfc-a653-4c0c-9524-374e630aa238$$s345724$$uhttps://digitalcollections.ohsu.edu/record/41305/files/ResearchWeek.2023.LiradaSilva.Andre.pdf
000041305 980__ $$aResearch Week
000041305 981__ $$aPublished$$b2023-07-20