TY  - GEN
AB  - Oxidative stress and neuroinflammation are widespread in the Parkinson’s disease (PD) brain and contribute to the synaptic degradation and dopaminergic cell loss that result in cognitive impairment and motor dysfunction. The compound Gardenin A (GA) has been shown to activate the NRF2-regulated antioxidant pathway and inhibit the NFkB-regulated pro-inflammatory pathway in a Drosophila model of PD.  Here, we evaluate the effects of GA on A53T alpha-synuclein overexpressing (A53TSyn) mice.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - The University of Alabama
AD  - The University of Alabama
AD  - Oregon Health and Science University
AU  - Gladen Kolarsky, Noah
AU  - Hack, Wyatt
AU  - Maitra, Urmila
AU  - Ciesla, Lukasz
AU  - Gray, Nora
DA  - 2023-07-21
DO  - 10.6083/bpxhc41333
DO  - doi
ID  - 41333
KW  - Neurobiology
KW  - Cell Biology
KW  - Molecular Biology
KW  - Parkinson Disease
KW  - Cognition
KW  - Cognitive Dysfunction
KW  - Parkinsonian Disorders
KW  - Neuroinflammatory Diseases
KW  - drosophila model
KW  - motor function
KW  - gardenin a
L1  - https://digitalcollections.ohsu.edu/record/41333/files/ResearchWeek.2023.GladenKolarsky.Noah.pdf
L2  - https://digitalcollections.ohsu.edu/record/41333/files/ResearchWeek.2023.GladenKolarsky.Noah.pdf
L4  - https://digitalcollections.ohsu.edu/record/41333/files/ResearchWeek.2023.GladenKolarsky.Noah.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/41333/files/ResearchWeek.2023.GladenKolarsky.Noah.pdf
N2  - Oxidative stress and neuroinflammation are widespread in the Parkinson’s disease (PD) brain and contribute to the synaptic degradation and dopaminergic cell loss that result in cognitive impairment and motor dysfunction. The compound Gardenin A (GA) has been shown to activate the NRF2-regulated antioxidant pathway and inhibit the NFkB-regulated pro-inflammatory pathway in a Drosophila model of PD.  Here, we evaluate the effects of GA on A53T alpha-synuclein overexpressing (A53TSyn) mice.
PB  - Oregon Health and Science University
PY  - 2023-07-21
T1  - Gardenin A decreases neuroinflammation, activates antioxidant response and improves cognitive and motor function in A53T alpha synuclein overexpressing mice
TI  - Gardenin A decreases neuroinflammation, activates antioxidant response and improves cognitive and motor function in A53T alpha synuclein overexpressing mice
UR  - https://digitalcollections.ohsu.edu/record/41333/files/ResearchWeek.2023.GladenKolarsky.Noah.pdf
Y1  - 2023-07-21
ER  -