000041333 001__ 41333
000041333 005__ 20240408094058.0
000041333 0247_ $$2doi$$a10.6083/bpxhc41333
000041333 037__ $$aIR
000041333 041__ $$aeng
000041333 245__ $$aGardenin A decreases neuroinflammation, activates antioxidant response and improves cognitive and motor function in A53T alpha synuclein overexpressing mice
000041333 260__ $$bOregon Health and Science University
000041333 269__ $$a2023-07-21
000041333 336__ $$aAbstract
000041333 520__ $$aOxidative stress and neuroinflammation are widespread in the Parkinson’s disease (PD) brain and contribute to the synaptic degradation and dopaminergic cell loss that result in cognitive impairment and motor dysfunction. The compound Gardenin A (GA) has been shown to activate the NRF2-regulated antioxidant pathway and inhibit the NFkB-regulated pro-inflammatory pathway in a Drosophila model of PD.  Here, we evaluate the effects of GA on A53T alpha-synuclein overexpressing (A53TSyn) mice.
000041333 540__ $$fCC BY
000041333 542__ $$fIn copyright - joint owners
000041333 650__ $$aNeurobiology$$022831
000041333 650__ $$aCell Biology$$017350
000041333 650__ $$aMolecular Biology$$022384
000041333 650__ $$aParkinson Disease$$023617
000041333 650__ $$aCognition$$016868
000041333 650__ $$aCognitive Dysfunction$$039814
000041333 650__ $$aParkinsonian Disorders$$032648
000041333 650__ $$aNeuroinflammatory Diseases$$013756
000041333 6531_ $$adrosophila model
000041333 6531_ $$amotor function
000041333 6531_ $$agardenin a
000041333 691__ $$aSchool of Medicine$$041369
000041333 692__ $$aDepartment of Neurology$$041431
000041333 7001_ $$aGladen Kolarsky, Noah$$uOregon Health and Science University$$041354
000041333 7001_ $$aHack, Wyatt$$uOregon Health and Science University$$041354
000041333 7001_ $$aMaitra, Urmila$$uThe University of Alabama
000041333 7001_ $$aCiesla, Lukasz$$uThe University of Alabama
000041333 7001_ $$aGray, Nora$$uOregon Health and Science University$$041354
000041333 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000041333 8564_ $$9e0168ca7-648a-425c-a732-7bf200129641$$s298064$$uhttps://digitalcollections.ohsu.edu/record/41333/files/ResearchWeek.2023.GladenKolarsky.Noah.pdf
000041333 980__ $$aResearch Week
000041333 981__ $$aPublished$$b2023-07-24