@article{IR, author = {Neff, Cody J. and Kolarsky, Noah Gladen and Hack, Wyatt and Brandes, Mikah and Mezza-Romero, Rob and Lockwood, Denesa and Quinn, Joseph and Vandenbark, Arthur and Gray, Nora}, url = {http://digitalcollections.ohsu.edu/record/41340}, title = {CD74 inhibitor DRhQ improves cognition and mitochondrial function and reduces neuroinflammation in 5xFAD mouse model of AB accumulation}, publisher = {Oregon Health and Science University}, abstract = {Neuroinflammation and mitochondrial dysfunction are early events in Alzheimer’s disease (AD) and contribute to neurodegeneration and cognitive impairment. The CD74-MIF (macrophage migration inhibitory factor) axis is a mediator of the neuroinflammatory response. DRhQ competitively inhibits MIF-CD74 binding and elicits beneficial effects in other neurodegenerative disease models. Here we evaluate its effects in β-amyloid (Aβ) overexpressing mice.}, number = {IR}, doi = {https://doi.org/10.6083/bpxhc41340}, recid = {41340}, address = {2023-07-25}, }