TY  - GEN
N2  - Neuroinflammation and mitochondrial dysfunction are early events in Alzheimer’s disease (AD) and contribute to neurodegeneration and cognitive impairment. The CD74-MIF (macrophage migration inhibitory factor) axis is a mediator of the neuroinflammatory response. DRhQ competitively inhibits MIF-CD74 binding and elicits beneficial effects in other neurodegenerative disease models. Here we evaluate its effects in β-amyloid (Aβ) overexpressing mice.
DO  - 10.6083/bpxhc41340
DO  - doi
AB  - Neuroinflammation and mitochondrial dysfunction are early events in Alzheimer’s disease (AD) and contribute to neurodegeneration and cognitive impairment. The CD74-MIF (macrophage migration inhibitory factor) axis is a mediator of the neuroinflammatory response. DRhQ competitively inhibits MIF-CD74 binding and elicits beneficial effects in other neurodegenerative disease models. Here we evaluate its effects in β-amyloid (Aβ) overexpressing mice.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - CD74 inhibitor DRhQ improves cognition and mitochondrial function and reduces neuroinflammation in 5xFAD mouse model of AB accumulation
DA  - 2023-07-25
AU  - Neff, Cody J.
AU  - Kolarsky, Noah Gladen
AU  - Hack, Wyatt
AU  - Brandes, Mikah
AU  - Mezza-Romero, Rob
AU  - Lockwood, Denesa
AU  - Quinn, Joseph
AU  - Vandenbark, Arthur
AU  - Gray, Nora
L1  - https://digitalcollections.ohsu.edu/record/41340/files/ResearchWeek.2023.Neff.Cody.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-07-25
ID  - 41340
L4  - https://digitalcollections.ohsu.edu/record/41340/files/ResearchWeek.2023.Neff.Cody.pdf
KW  - Neurobiology
KW  - Neurosciences
KW  - Alzheimer Disease
KW  - Cognition
KW  - Neuroinflammatory Diseases
KW  - Mice
KW  - Models, Animal
KW  - Dementia
KW  - Cognitive Dysfunction
KW  - Neuroinflammatory Diseases
KW  - mitochondrial dysfunction
KW  - neurodegeneration
TI  - CD74 inhibitor DRhQ improves cognition and mitochondrial function and reduces neuroinflammation in 5xFAD mouse model of AB accumulation
Y1  - 2023-07-25
L2  - https://digitalcollections.ohsu.edu/record/41340/files/ResearchWeek.2023.Neff.Cody.pdf
LK  - https://digitalcollections.ohsu.edu/record/41340/files/ResearchWeek.2023.Neff.Cody.pdf
UR  - https://digitalcollections.ohsu.edu/record/41340/files/ResearchWeek.2023.Neff.Cody.pdf
ER  -