000041340 001__ 41340
000041340 005__ 20240328104749.0
000041340 0247_ $$2doi$$a10.6083/bpxhc41340
000041340 037__ $$aIR
000041340 041__ $$aeng
000041340 245__ $$aCD74 inhibitor DRhQ improves cognition and mitochondrial function and reduces neuroinflammation in 5xFAD mouse model of AB accumulation
000041340 260__ $$bOregon Health and Science University
000041340 269__ $$a2023-07-25
000041340 336__ $$aAbstract
000041340 520__ $$aNeuroinflammation and mitochondrial dysfunction are early events in Alzheimer’s disease (AD) and contribute to neurodegeneration and cognitive impairment. The CD74-MIF (macrophage migration inhibitory factor) axis is a mediator of the neuroinflammatory response. DRhQ competitively inhibits MIF-CD74 binding and elicits beneficial effects in other neurodegenerative disease models. Here we evaluate its effects in β-amyloid (Aβ) overexpressing mice.
000041340 540__ $$fCC BY
000041340 542__ $$fIn copyright - joint owners
000041340 650__ $$aNeurobiology$$022831
000041340 650__ $$aNeurosciences$$022870
000041340 650__ $$aAlzheimer Disease$$014513
000041340 650__ $$aCognition$$016868
000041340 650__ $$aNeuroinflammatory Diseases$$013756
000041340 650__ $$aMice$$036842
000041340 650__ $$aModels, Animal$$033025
000041340 650__ $$aDementia$$017461
000041340 650__ $$aCognitive Dysfunction$$039814
000041340 650__ $$aNeuroinflammatory Diseases$$013756
000041340 6531_ $$amitochondrial dysfunction
000041340 6531_ $$aneurodegeneration
000041340 691__ $$aSchool of Medicine$$041369
000041340 692__ $$aDepartment of Neurology$$041431
000041340 7001_ $$aNeff, Cody J.$$uOregon Health and Science University$$041354
000041340 7001_ $$aKolarsky, Noah Gladen$$uOregon Health and Science University$$041354
000041340 7001_ $$aHack, Wyatt$$uOregon Health and Science University$$041354
000041340 7001_ $$aBrandes, Mikah$$uOregon Health and Science University$$041354
000041340 7001_ $$aMezza-Romero, Rob$$uOregon Health and Science University$$041354
000041340 7001_ $$aLockwood, Denesa$$uOregon Health and Science University$$041354
000041340 7001_ $$aQuinn, Joseph$$uOregon Health and Science University$$041354
000041340 7001_ $$aVandenbark, Arthur$$uOregon Health and Science University$$041354
000041340 7001_ $$aGray, Nora$$uOregon Health and Science University$$041354
000041340 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000041340 8564_ $$937a36cd2-8aca-4fbe-bd89-a194209cff49$$s31047$$uhttps://digitalcollections.ohsu.edu/record/41340/files/ResearchWeek.2023.Neff.Cody.pdf
000041340 980__ $$aResearch Week
000041340 981__ $$aPublished$$b2023-07-25