TY  - GEN
N2  - Patients with obstructive hypertrophic cardiomyopathy (oHCM) frequently present with heart failure symptoms refractory to medical therapy and require septal myectomy (SM). The magnitude of benefit from SM is thought to be better than the recently reported data from EXPLORER-HCM and REDWOOD-HCM trials. We prospectively investigated the association between SM, patient-reported 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ-12) and physician-reported NYHA class in a community-based cohort of oHCM. SM ± submitral valve repair is associated with improvement in NYHA class and KCCQ-12 but with a varying magnitude of benefit.
DO  - 10.6083/bpxhc41530
DO  - doi
AB  - Patients with obstructive hypertrophic cardiomyopathy (oHCM) frequently present with heart failure symptoms refractory to medical therapy and require septal myectomy (SM). The magnitude of benefit from SM is thought to be better than the recently reported data from EXPLORER-HCM and REDWOOD-HCM trials. We prospectively investigated the association between SM, patient-reported 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ-12) and physician-reported NYHA class in a community-based cohort of oHCM. SM ± submitral valve repair is associated with improvement in NYHA class and KCCQ-12 but with a varying magnitude of benefit.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Improved NYHA class and KCCQ-12 after septal  myectomy in patients with obstructive hypertrophic cardiomyopathy
DA  - 2023-08-15
AU  - Cambron, Claire
AU  - Lin, Lucy
AU  - Kim, Morris
AU  - Rashdan, Lana
AU  - Li, Sarah
AU  - Zhao, Yuanzi
AU  - Graham, Kellie
AU  - Fischer, Katherine
AU  - Nazer, Babak
AU  - Heitner, Stephen B.
AU  - Song, Howard
AU  - Masri, Ahmad
L1  - https://digitalcollections.ohsu.edu/record/41530/files/ResearchWeek.2023.Cambron.Claire.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-08-15
ID  - 41530
L4  - https://digitalcollections.ohsu.edu/record/41530/files/ResearchWeek.2023.Cambron.Claire.pdf
KW  - Female
KW  - Cardiac Myosins
KW  - Prevalence
KW  - Placebo Effect
KW  - Prospective Studies
KW  - Cardiomyopathy, Hypertrophic
KW  - Heart Failure
KW  - Surveys and Questionnaires
KW  - Physicians
KW  - Humans
KW  - Cardiology
KW  - septal myectomy
KW  - cardiac myosin inhibitors
TI  - Improved NYHA class and KCCQ-12 after septal  myectomy in patients with obstructive hypertrophic cardiomyopathy
Y1  - 2023-08-15
L2  - https://digitalcollections.ohsu.edu/record/41530/files/ResearchWeek.2023.Cambron.Claire.pdf
LK  - https://digitalcollections.ohsu.edu/record/41530/files/ResearchWeek.2023.Cambron.Claire.pdf
UR  - https://digitalcollections.ohsu.edu/record/41530/files/ResearchWeek.2023.Cambron.Claire.pdf
ER  -