000041530 001__ 41530
000041530 005__ 20240410075904.0
000041530 0247_ $$2doi$$a10.6083/bpxhc41530
000041530 037__ $$aIR
000041530 041__ $$aeng
000041530 245__ $$aImproved NYHA class and KCCQ-12 after septal  myectomy in patients with obstructive hypertrophic cardiomyopathy
000041530 260__ $$bOregon Health and Science University
000041530 269__ $$a2023-08-15
000041530 336__ $$aAbstract
000041530 520__ $$aPatients with obstructive hypertrophic cardiomyopathy (oHCM) frequently present with heart failure symptoms refractory to medical therapy and require septal myectomy (SM). The magnitude of benefit from SM is thought to be better than the recently reported data from EXPLORER-HCM and REDWOOD-HCM trials. We prospectively investigated the association between SM, patient-reported 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ-12) and physician-reported NYHA class in a community-based cohort of oHCM. SM ± submitral valve repair is associated with improvement in NYHA class and KCCQ-12 but with a varying magnitude of benefit.
000041530 540__ $$fCC BY
000041530 542__ $$fIn copyright - joint owners
000041530 650__ $$aFemale$$018941
000041530 650__ $$aCardiac Myosins$$033137
000041530 650__ $$aPrevalence$$028804
000041530 650__ $$aPlacebo Effect$$028799
000041530 650__ $$aProspective Studies$$024706
000041530 650__ $$aCardiomyopathy, Hypertrophic$$016146
000041530 650__ $$aHeart Failure$$019939
000041530 650__ $$aSurveys and Questionnaires$$025037
000041530 650__ $$aPhysicians$$024116
000041530 650__ $$aHumans$$020376
000041530 650__ $$aCardiology$$016143
000041530 6531_ $$aseptal myectomy
000041530 6531_ $$acardiac myosin inhibitors
000041530 692__ $$aHypertrophic Cardiomyopathy Center
000041530 692__ $$aOHSU Knight Cardiovascular Institute$$041489
000041530 7001_ $$aCambron, Claire$$uOregon Health and Science University$$041354
000041530 7001_ $$aLin, Lucy$$uOregon Health and Science University$$041354
000041530 7001_ $$aKim, Morris$$uOregon Health and Science University$$041354
000041530 7001_ $$aRashdan, Lana$$uOregon Health and Science University$$041354
000041530 7001_ $$aLi, Sarah$$uOregon Health and Science University$$041354
000041530 7001_ $$aZhao, Yuanzi$$uOregon Health and Science University$$041354
000041530 7001_ $$aGraham, Kellie$$uOregon Health and Science University$$041354
000041530 7001_ $$aFischer, Katherine$$uOregon Health and Science University$$041354
000041530 7001_ $$aNazer, Babak$$uOregon Health and Science University$$041354
000041530 7001_ $$aHeitner, Stephen B.$$uOregon Health and Science University$$041354
000041530 7001_ $$aSong, Howard$$uOregon Health and Science University$$041354
000041530 7001_ $$aMasri, Ahmad$$uOregon Health and Science University$$041354
000041530 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000041530 8564_ $$947e1a18a-9b6b-4c93-8926-48736517d10a$$s140551$$uhttps://digitalcollections.ohsu.edu/record/41530/files/ResearchWeek.2023.Cambron.Claire.pdf
000041530 980__ $$aResearch Week
000041530 981__ $$aPublished$$b2023-08-15