TY  - GEN
N2  - Immune checkpoint blockade (ICB) has revolutionized the ways in which we treat some cancers, producing durable responses. However, many patients fail to respond to ICB. It is theorized that patients require tumor-specific T cells to respond effectively to ICB, but aged individuals have compromised T cell diversity partially due to reduced thymic output. The goal of this dissertation is to determine the role of a common target of ICB, programmed cell death protein 1 (PD-1), in regulating T cell development in the thymus.
DO  - 10.6083/bpxhc41548
DO  - doi
AB  - Immune checkpoint blockade (ICB) has revolutionized the ways in which we treat some cancers, producing durable responses. However, many patients fail to respond to ICB. It is theorized that patients require tumor-specific T cells to respond effectively to ICB, but aged individuals have compromised T cell diversity partially due to reduced thymic output. The goal of this dissertation is to determine the role of a common target of ICB, programmed cell death protein 1 (PD-1), in regulating T cell development in the thymus.
AD  - Oregon Health and Science University
T1  - Modulating T cell development with implications for response to immune checkpoint blockade
DA  - 2023-08-16
AU  - Caruso, Breanna
L1  - https://digitalcollections.ohsu.edu/record/41548/files/Caruso.Breanna.2023.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-08-16
ID  - 41548
L4  - https://digitalcollections.ohsu.edu/record/41548/files/Caruso.Breanna.2023.pdf
KW  - Thymus Gland
KW  - Programmed Cell Death 1 Receptor
KW  - T-Lymphocytes, Regulatory
KW  - Interleukin-2
KW  - Prostatic Neoplasms
KW  - pd-1 protein
KW  - regulatory t cell
KW  - il-2
KW  - prostate cancer
KW  - androgen deprivation therapy
TI  - Modulating T cell development with implications for response to immune checkpoint blockade
Y1  - 2023-08-16
L2  - https://digitalcollections.ohsu.edu/record/41548/files/Caruso.Breanna.2023.pdf
LK  - https://digitalcollections.ohsu.edu/record/41548/files/Caruso.Breanna.2023.pdf
UR  - https://digitalcollections.ohsu.edu/record/41548/files/Caruso.Breanna.2023.pdf
ER  -