000041548 001__ 41548
000041548 005__ 20240124114339.0
000041548 0247_ $$2doi$$a10.6083/bpxhc41548
000041548 037__ $$aETD
000041548 041__ $$aeng
000041548 245__ $$aModulating T cell development with implications for response to immune checkpoint blockade
000041548 260__ $$bOregon Health and Science University
000041548 269__ $$a2023-08-16
000041548 336__ $$aDissertation
000041548 502__ $$bPh.D.
000041548 502__ $$gCancer Biology
000041548 520__ $$aImmune checkpoint blockade (ICB) has revolutionized the ways in which we treat some cancers, producing durable responses. However, many patients fail to respond to ICB. It is theorized that patients require tumor-specific T cells to respond effectively to ICB, but aged individuals have compromised T cell diversity partially due to reduced thymic output. The goal of this dissertation is to determine the role of a common target of ICB, programmed cell death protein 1 (PD-1), in regulating T cell development in the thymus.
000041548 540__ $$fCC BY
000041548 542__ $$fIn copyright - single owner
000041548 650__ $$aThymus Gland$$027057
000041548 650__ $$aProgrammed Cell Death 1 Receptor$$039852
000041548 650__ $$aT-Lymphocytes, Regulatory$$036362
000041548 650__ $$aInterleukin-2$$020918
000041548 650__ $$aProstatic Neoplasms$$024731
000041548 6531_ $$apd-1 protein
000041548 6531_ $$aregulatory t cell
000041548 6531_ $$ail-2
000041548 6531_ $$aprostate cancer
000041548 6531_ $$aandrogen deprivation therapy
000041548 691__ $$aSchool of Medicine$$041369
000041548 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000041548 7001_ $$aCaruso, Breanna$$uOregon Health and Science University$$041354
000041548 8564_ $$9d7dfd6b3-bf44-459b-874b-61c2a08171d0$$s12140518$$uhttps://digitalcollections.ohsu.edu/record/41548/files/Caruso.Breanna.2023.pdf
000041548 909CO $$ooai:digitalcollections.ohsu.edu:41548$$pstudent-work
000041548 980__ $$aTheses and Dissertations
000041548 981__ $$aPublished$$b2023-08-17