@article{IR,
      author = {Klocke, Christopher and Moran, Amy and McWeeney, Shannon  and Adey, Andrew and Wu, Guanming},
      url = {http://digitalcollections.ohsu.edu/record/41598},
      title = {Identification of cellular interactions in the tumor  immune microenvironment underlying CD8 T cell exhaustion},
      publisher = {Oregon Health and Science University},
      abstract = {Immune checkpoint inhibitors have shown success in  treating a subset of patients with certain late-stage  cancers. However, these treatments fail in many other  patients, due to mechanisms that have yet to be fully  characterized. The process of T cell exhaustion, by which T  cells become dysfunctional in response to extended exposure  to antigen, has been implicated in immunotherapy  resistance. We constructed an analysis framework to first  rank human skin tumor samples by degree of exhaustion in  tumor-infiltrating CD8 T cells and then identify immune  cell type-specific gene regulatory network patterns  significantly associated with T cell exhaustion.},
      number = {IR},
      doi = {https://doi.org/10.6083/bpxhc41598},
      recid = {41598},
      address = {2023-08-18},
}