TY  - GEN
AB  - Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, due to mechanisms that have yet to be fully characterized. The process of T cell exhaustion, by which T cells become dysfunctional in response to extended exposure to antigen, has been implicated in immunotherapy resistance. We constructed an analysis framework to first rank human skin tumor samples by degree of exhaustion in tumor-infiltrating CD8 T cells and then identify immune cell type-specific gene regulatory network patterns significantly associated with T cell exhaustion.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Klocke, Christopher
AU  - Moran, Amy
AU  - McWeeney, Shannon
AU  - Adey, Andrew
AU  - Wu, Guanming
DA  - 2023-08-18
DO  - 10.6083/bpxhc41598
DO  - doi
ID  - 41598
KW  - Computational Biology
KW  - Immunotherapy
KW  - Single-Cell Gene Expression Analysis
KW  - Gene Regulatory Networks
KW  - bioinformatics
KW  - cancer immunology
KW  - scrna-seq
KW  - cd8 t cell exhaustion
KW  - neoplasms
L1  - https://digitalcollections.ohsu.edu/record/41598/files/ResearchWeek.2023.Klocke.Christopher.pdf
L2  - https://digitalcollections.ohsu.edu/record/41598/files/ResearchWeek.2023.Klocke.Christopher.pdf
L4  - https://digitalcollections.ohsu.edu/record/41598/files/ResearchWeek.2023.Klocke.Christopher.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/41598/files/ResearchWeek.2023.Klocke.Christopher.pdf
N2  - Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, due to mechanisms that have yet to be fully characterized. The process of T cell exhaustion, by which T cells become dysfunctional in response to extended exposure to antigen, has been implicated in immunotherapy resistance. We constructed an analysis framework to first rank human skin tumor samples by degree of exhaustion in tumor-infiltrating CD8 T cells and then identify immune cell type-specific gene regulatory network patterns significantly associated with T cell exhaustion.
PB  - Oregon Health and Science University
PY  - 2023-08-18
T1  - Identification of cellular interactions in the tumor immune microenvironment underlying CD8 T cell exhaustion
TI  - Identification of cellular interactions in the tumor immune microenvironment underlying CD8 T cell exhaustion
UR  - https://digitalcollections.ohsu.edu/record/41598/files/ResearchWeek.2023.Klocke.Christopher.pdf
Y1  - 2023-08-18
ER  -