TY  - GEN
N2  - Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, due to mechanisms that have yet to be fully characterized. The process of T cell exhaustion, by which T cells become dysfunctional in response to extended exposure to antigen, has been implicated in immunotherapy resistance. We constructed an analysis framework to first rank human skin tumor samples by degree of exhaustion in tumor-infiltrating CD8 T cells and then identify immune cell type-specific gene regulatory network patterns significantly associated with T cell exhaustion.
DO  - 10.6083/bpxhc41598
DO  - doi
AB  - Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, due to mechanisms that have yet to be fully characterized. The process of T cell exhaustion, by which T cells become dysfunctional in response to extended exposure to antigen, has been implicated in immunotherapy resistance. We constructed an analysis framework to first rank human skin tumor samples by degree of exhaustion in tumor-infiltrating CD8 T cells and then identify immune cell type-specific gene regulatory network patterns significantly associated with T cell exhaustion.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Identification of cellular interactions in the tumor immune microenvironment underlying CD8 T cell exhaustion
DA  - 2023-08-18
AU  - Klocke, Christopher
AU  - Moran, Amy
AU  - McWeeney, Shannon
AU  - Adey, Andrew
AU  - Wu, Guanming
L1  - https://digitalcollections.ohsu.edu/record/41598/files/ResearchWeek.2023.Klocke.Christopher.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-08-18
ID  - 41598
L4  - https://digitalcollections.ohsu.edu/record/41598/files/ResearchWeek.2023.Klocke.Christopher.pdf
KW  - Computational Biology
KW  - Immunotherapy
KW  - Single-Cell Gene Expression Analysis
KW  - Gene Regulatory Networks
KW  - bioinformatics
KW  - cancer immunology
KW  - scrna-seq
KW  - cd8 t cell exhaustion
KW  - neoplasms
TI  - Identification of cellular interactions in the tumor immune microenvironment underlying CD8 T cell exhaustion
Y1  - 2023-08-18
L2  - https://digitalcollections.ohsu.edu/record/41598/files/ResearchWeek.2023.Klocke.Christopher.pdf
LK  - https://digitalcollections.ohsu.edu/record/41598/files/ResearchWeek.2023.Klocke.Christopher.pdf
UR  - https://digitalcollections.ohsu.edu/record/41598/files/ResearchWeek.2023.Klocke.Christopher.pdf
ER  -