000041598 001__ 41598
000041598 005__ 20240409133119.0
000041598 0247_ $$2doi$$a10.6083/bpxhc41598
000041598 037__ $$aIR
000041598 041__ $$aeng
000041598 245__ $$aIdentification of cellular interactions in the tumor immune microenvironment underlying CD8 T cell exhaustion
000041598 260__ $$bOregon Health and Science University
000041598 269__ $$a2023-08-18
000041598 336__ $$aAbstract
000041598 520__ $$aImmune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, due to mechanisms that have yet to be fully characterized. The process of T cell exhaustion, by which T cells become dysfunctional in response to extended exposure to antigen, has been implicated in immunotherapy resistance. We constructed an analysis framework to first rank human skin tumor samples by degree of exhaustion in tumor-infiltrating CD8 T cells and then identify immune cell type-specific gene regulatory network patterns significantly associated with T cell exhaustion.
000041598 540__ $$fCC BY
000041598 542__ $$fIn copyright - joint owners
000041598 650__ $$aComputational Biology$$031511
000041598 650__ $$aImmunotherapy$$020724
000041598 650__ $$aSingle-Cell Gene Expression Analysis$$013872
000041598 650__ $$aGene Regulatory Networks$$037326
000041598 6531_ $$abioinformatics
000041598 6531_ $$acancer immunology
000041598 6531_ $$ascrna-seq
000041598 6531_ $$acd8 t cell exhaustion
000041598 6531_ $$aneoplasms
000041598 691__ $$aSchool of Medicine$$041369
000041598 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000041598 7001_ $$aKlocke, Christopher$$uOregon Health and Science University$$041354
000041598 7001_ $$aMoran, Amy$$uOregon Health and Science University$$041354
000041598 7001_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354
000041598 7001_ $$aAdey, Andrew$$uOregon Health and Science University$$041354
000041598 7001_ $$aWu, Guanming$$uOregon Health and Science University$$041354
000041598 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000041598 8564_ $$905c22065-3737-4c4e-bcd6-8f227d4e43d5$$s99281$$uhttps://digitalcollections.ohsu.edu/record/41598/files/ResearchWeek.2023.Klocke.Christopher.pdf
000041598 980__ $$aResearch Week
000041598 981__ $$aPublished$$b2023-08-18