TY  - GEN
N2  - Axial spondyloarthritis (axSpA) is a chronic inflammatory disease, that affects the sacroiliac joints and spine, with inflammation in either gut, eye, and/or skin, and a strong association with the human leukocyte antigen (HLA)-B27 allele. We aim to determine the risk genes/variants required in addition to HLA-B27 for disease development. The proposed study has the potential to define the additional risk genes/variants required in axSpA, leading to genetic stratification of the disease, and unraveling novel targets for axSpA treatment and prevention strategies.
DO  - 10.6083/bpxhc41603
DO  - doi
AB  - Axial spondyloarthritis (axSpA) is a chronic inflammatory disease, that affects the sacroiliac joints and spine, with inflammation in either gut, eye, and/or skin, and a strong association with the human leukocyte antigen (HLA)-B27 allele. We aim to determine the risk genes/variants required in addition to HLA-B27 for disease development. The proposed study has the potential to define the additional risk genes/variants required in axSpA, leading to genetic stratification of the disease, and unraveling novel targets for axSpA treatment and prevention strategies.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - To determine non-HLA-B27 risk genes/variants underlying axial spondyloarthritis
DA  - 2023-08-18
AU  - Furst, Alec
AU  - Bringenberg, Henry
AU  - Davis, John
AU  - Davin, Sean
AU  - Ahuja, Jasvinder
AU  - Gill, Tejpal
L1  - https://digitalcollections.ohsu.edu/record/41603/files/ResearchWeek.2023.Furst.Alec.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-08-18
ID  - 41603
L4  - https://digitalcollections.ohsu.edu/record/41603/files/ResearchWeek.2023.Furst.Alec.pdf
KW  - Axial Spondyloarthritis
KW  - HLA Antigens
KW  - HLA-B27 Antigen
KW  - Arthritis
KW  - Inflammatory Bowel Diseases
KW  - Whole Genome Sequencing
KW  - Spondylitis
KW  - Ankylosis
KW  - Spinal Diseases
KW  - axSpA
KW  - rat models
KW  - IDB
KW  - rodent models
KW  - human leukocyte antigen
TI  - To determine non-HLA-B27 risk genes/variants underlying axial spondyloarthritis
Y1  - 2023-08-18
L2  - https://digitalcollections.ohsu.edu/record/41603/files/ResearchWeek.2023.Furst.Alec.pdf
LK  - https://digitalcollections.ohsu.edu/record/41603/files/ResearchWeek.2023.Furst.Alec.pdf
UR  - https://digitalcollections.ohsu.edu/record/41603/files/ResearchWeek.2023.Furst.Alec.pdf
ER  -