000041603 001__ 41603
000041603 005__ 20240418090223.0
000041603 0247_ $$2doi$$a10.6083/bpxhc41603
000041603 037__ $$aIR
000041603 041__ $$aeng
000041603 245__ $$aTo determine non-HLA-B27 risk genes/variants underlying axial spondyloarthritis
000041603 260__ $$bOregon Health and Science University
000041603 269__ $$a2023-08-18
000041603 336__ $$aAbstract
000041603 520__ $$aAxial spondyloarthritis (axSpA) is a chronic inflammatory disease, that affects the sacroiliac joints and spine, with inflammation in either gut, eye, and/or skin, and a strong association with the human leukocyte antigen (HLA)-B27 allele. We aim to determine the risk genes/variants required in addition to HLA-B27 for disease development. The proposed study has the potential to define the additional risk genes/variants required in axSpA, leading to genetic stratification of the disease, and unraveling novel targets for axSpA treatment and prevention strategies.
000041603 540__ $$fCC BY
000041603 542__ $$fIn copyright - joint owners
000041603 650__ $$aAxial Spondyloarthritis$$013651
000041603 650__ $$aHLA Antigens$$020260
000041603 650__ $$aHLA-B27 Antigen$$028654
000041603 650__ $$aArthritis$$015092
000041603 650__ $$aInflammatory Bowel Diseases$$028222
000041603 650__ $$aWhole Genome Sequencing$$012142
000041603 650__ $$aSpondylitis$$026327
000041603 650__ $$aAnkylosis$$014795
000041603 650__ $$aSpinal Diseases$$026285
000041603 6531_ $$aaxSpA
000041603 6531_ $$arat models
000041603 6531_ $$aIDB
000041603 6531_ $$arodent models
000041603 6531_ $$ahuman leukocyte antigen
000041603 692__ $$aCasey Eye Institute$$041381
000041603 7001_ $$aFurst, Alec$$uOregon Health and Science University$$041354
000041603 7001_ $$aBringenberg, Henry$$uOregon Health and Science University$$041354
000041603 7001_ $$aDavis, John$$uOregon Health and Science University$$041354
000041603 7001_ $$aDavin, Sean$$uOregon Health and Science University$$041354
000041603 7001_ $$aAhuja, Jasvinder$$uOregon Health and Science University$$041354
000041603 7001_ $$aGill, Tejpal$$uOregon Health and Science University$$041354
000041603 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000041603 8564_ $$906f6b8bc-ae3d-4d7b-837c-0dd3f6f95c3e$$s49841$$uhttps://digitalcollections.ohsu.edu/record/41603/files/ResearchWeek.2023.Furst.Alec.pdf
000041603 980__ $$aResearch Week
000041603 981__ $$aPublished$$b2023-08-18