TY - GEN N2 - Freezing of gait (FOG) is one of the most debilitating features of Parkinson’s disease (PD). FOG may be due to a lack of central inhibition, as people with PD and FOG (PD+FOG) have difficulty inhibiting postural preparation prior to initiating stepping. We recently demonstrated that presynaptic inhibition (PSI) in the spinal cord, is crucial for coordinating postural preparation with step initiation. To investigate the feasibility of vibrotactile feedback in restoring PSI and overcome step initiation failure in PD+FOG. DO - 10.6083/bpxhc41613 DO - doi AB - Freezing of gait (FOG) is one of the most debilitating features of Parkinson’s disease (PD). FOG may be due to a lack of central inhibition, as people with PD and FOG (PD+FOG) have difficulty inhibiting postural preparation prior to initiating stepping. We recently demonstrated that presynaptic inhibition (PSI) in the spinal cord, is crucial for coordinating postural preparation with step initiation. To investigate the feasibility of vibrotactile feedback in restoring PSI and overcome step initiation failure in PD+FOG. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Federal University of ABC AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University T1 - Vibration to restore presynaptic inhibition and alleviate start hesitation in people with Parkinson’s disease and freezing of gait: a study protocol DA - 2023-08-21 AU - Chitlur, Tanisha AU - Liu, William AU - Boari, Daniel AU - Horak, Fay B. AU - Mancini, Martina AU - Silva-Batista, Carla L1 - https://digitalcollections.ohsu.edu/record/41613/files/ResearchWeek.2023.Chitlur.Tanisha.pdf PB - Oregon Health and Science University LA - eng PY - 2023-08-21 ID - 41613 L4 - https://digitalcollections.ohsu.edu/record/41613/files/ResearchWeek.2023.Chitlur.Tanisha.pdf KW - Gait Disorders, Neurologic KW - Vibration KW - Parkinson Disease KW - Feedback KW - Goals KW - Humans KW - Parkinsonian Disorders KW - Movement Disorders KW - Gait KW - vibrotactile stimulation KW - freezing of gait KW - presynaptic inhibition TI - Vibration to restore presynaptic inhibition and alleviate start hesitation in people with Parkinson’s disease and freezing of gait: a study protocol Y1 - 2023-08-21 L2 - https://digitalcollections.ohsu.edu/record/41613/files/ResearchWeek.2023.Chitlur.Tanisha.pdf LK - https://digitalcollections.ohsu.edu/record/41613/files/ResearchWeek.2023.Chitlur.Tanisha.pdf UR - https://digitalcollections.ohsu.edu/record/41613/files/ResearchWeek.2023.Chitlur.Tanisha.pdf ER -