TY  - GEN
N2  - Metastatic spread of cancer is responsible for the vast majority of cancer-related deaths highlighting the need to better understand the cellular mechanisms underlying this phase of cancer, and to monitor disease progression. Our team combines the discovery of a novel circulating tumor cell population, that co-expresses cancer cell and immune cell epitopes (called a hybrid cell), cutting-edge multiplex cyclic immunofluorescence (cyCIF) for interrogation of large panels of proteins on the same tissue section or blood smear, and powerful software (QITissue) that allows for the visualization and analysis of many biomarkers at once. This combination creates a platform that supports non-invasive, real-time monitoring of disease evolution. We set out to determine if disseminated or peripheral blood hybrid cells (called circulating hybrid cells, CHCs) harbored identical expression profiles as tissue-bound hybrid cells.
DO  - 10.6083/bpxhc41614
DO  - doi
AB  - Metastatic spread of cancer is responsible for the vast majority of cancer-related deaths highlighting the need to better understand the cellular mechanisms underlying this phase of cancer, and to monitor disease progression. Our team combines the discovery of a novel circulating tumor cell population, that co-expresses cancer cell and immune cell epitopes (called a hybrid cell), cutting-edge multiplex cyclic immunofluorescence (cyCIF) for interrogation of large panels of proteins on the same tissue section or blood smear, and powerful software (QITissue) that allows for the visualization and analysis of many biomarkers at once. This combination creates a platform that supports non-invasive, real-time monitoring of disease evolution. We set out to determine if disseminated or peripheral blood hybrid cells (called circulating hybrid cells, CHCs) harbored identical expression profiles as tissue-bound hybrid cells.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Ultra-high content analysis of circulating and solid tumor cells
DA  - 2023-08-21
AU  - Whalen, Riley
AU  - Jones, Jocelyn
AU  - Anderson, Ashley N.
AU  - Sims, Zachary
AU  - Chang, Young Hwan
AU  - Gibbs, Summer L.
AU  - Wong, Melissa H.
L1  - https://digitalcollections.ohsu.edu/record/41614/files/ResearchWeek.2023.Whalen.Riley.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-08-21
ID  - 41614
L4  - https://digitalcollections.ohsu.edu/record/41614/files/ResearchWeek.2023.Whalen.Riley.pdf
KW  - Neoplasms
KW  - Lymphatic Metastasis
KW  - Biomarkers
KW  - Neoplastic Cells, Circulating
KW  - Hybrid Cells
KW  - cancer
KW  - QITissue
KW  - circulating hybrid cells
KW  - metastatic disease
TI  - Ultra-high content analysis of circulating and solid tumor cells
Y1  - 2023-08-21
L2  - https://digitalcollections.ohsu.edu/record/41614/files/ResearchWeek.2023.Whalen.Riley.pdf
LK  - https://digitalcollections.ohsu.edu/record/41614/files/ResearchWeek.2023.Whalen.Riley.pdf
UR  - https://digitalcollections.ohsu.edu/record/41614/files/ResearchWeek.2023.Whalen.Riley.pdf
ER  -