000041614 001__ 41614
000041614 005__ 20240418105012.0
000041614 0247_ $$2doi$$a10.6083/bpxhc41614
000041614 037__ $$aIR
000041614 041__ $$aeng
000041614 245__ $$aUltra-high content analysis of circulating and solid tumor cells
000041614 260__ $$bOregon Health and Science University
000041614 269__ $$a2023-08-21
000041614 336__ $$aAbstract
000041614 520__ $$aMetastatic spread of cancer is responsible for the vast majority of cancer-related deaths highlighting the need to better understand the cellular mechanisms underlying this phase of cancer, and to monitor disease progression. Our team combines the discovery of a novel circulating tumor cell population, that co-expresses cancer cell and immune cell epitopes (called a hybrid cell), cutting-edge multiplex cyclic immunofluorescence (cyCIF) for interrogation of large panels of proteins on the same tissue section or blood smear, and powerful software (QITissue) that allows for the visualization and analysis of many biomarkers at once. This combination creates a platform that supports non-invasive, real-time monitoring of disease evolution. We set out to determine if disseminated or peripheral blood hybrid cells (called circulating hybrid cells, CHCs) harbored identical expression profiles as tissue-bound hybrid cells.
000041614 540__ $$fCC BY
000041614 542__ $$fIn copyright - joint owners
000041614 650__ $$aNeoplasms$$022758
000041614 650__ $$aLymphatic Metastasis$$021682
000041614 650__ $$aBiomarkers$$028395
000041614 650__ $$aNeoplastic Cells, Circulating$$022749
000041614 650__ $$aHybrid Cells$$020394
000041614 6531_ $$acancer
000041614 6531_ $$aQITissue
000041614 6531_ $$acirculating hybrid cells
000041614 6531_ $$ametastatic disease
000041614 691__ $$aSchool of Medicine$$041369
000041614 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000041614 7001_ $$aWhalen, Riley$$uOregon Health and Science University$$041354
000041614 7001_ $$aJones, Jocelyn$$uOregon Health and Science University$$041354
000041614 7001_ $$aAnderson, Ashley N.$$uOregon Health and Science University$$041354
000041614 7001_ $$aSims, Zachary$$uOregon Health and Science University$$041354
000041614 7001_ $$aChang, Young Hwan$$uOregon Health and Science University$$041354
000041614 7001_ $$aGibbs, Summer L.$$uOregon Health and Science University$$041354
000041614 7001_ $$aWong, Melissa H.$$uOregon Health and Science University$$041354
000041614 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000041614 8564_ $$99e6c56e9-62ac-4e39-9687-32d218bc6c2b$$s53164$$uhttps://digitalcollections.ohsu.edu/record/41614/files/ResearchWeek.2023.Whalen.Riley.pdf
000041614 980__ $$aResearch Week
000041614 981__ $$aPublished$$b2023-08-21