000041619 001__ 41619 000041619 005__ 20240328094443.0 000041619 0247_ $$2doi$$a10.6083/bpxhc41619 000041619 037__ $$aIR 000041619 041__ $$aeng 000041619 245__ $$aCardiac function in a mouse model of carcinoid disease 000041619 260__ $$bOregon Health and Science University 000041619 269__ $$a2023-08-21 000041619 336__ $$aAbstract 000041619 520__ $$aCarcinoid tumors are neuroendocrine tumors which release prostaglandins and biogenic amines that can impact the cardiovascular system.1 In consequence, patients with metastatic disease can develop carcinoid syndrome characterized by flushing, tachycardia and syncope. The physiologic mechanisms that contribute to this hemodynamic instability are not well understood. Therefore, our study sought to establish a mouse model of carcinoid tumor metastasis that could be used to assess cardiovascular function. 000041619 540__ $$fCC BY 000041619 542__ $$fIn copyright - joint owners 000041619 650__ $$aCarcinoid Heart Disease$$016110 000041619 650__ $$aMalignant Carcinoid Syndrome$$021767 000041619 650__ $$aDisease Models, Animal$$017932 000041619 650__ $$aMice$$036842 000041619 650__ $$aMice, Inbred BALB C$$022238 000041619 650__ $$aLiver Neoplasms$$021594 000041619 650__ $$aNeoplasm Metastasis$$022751 000041619 650__ $$aCarcinoid Tumor$$016111 000041619 650__ $$aNeuroendocrine Tumors$$030745 000041619 6531_ $$aliver cancer 000041619 6531_ $$arodent models 000041619 692__ $$aBasic Medical Sciences 000041619 7001_ $$aPenrose, Sofia$$uWestern University of Health Sciences, COMP-NW 000041619 7001_ $$aKuehn, Sydney 000041619 7001_ $$aMcCully, Belinda 000041619 711__ $$aResearch Week$$uOregon Health and Science University$$d2023 000041619 7201_ $$aPommier, Rodney$$eCollaborator$$7Personal 000041619 8564_ $$966442fc4-1c90-4f66-b456-9ac66ae55eeb$$s77047$$uhttps://digitalcollections.ohsu.edu/record/41619/files/ResearchWeek.2023.Penrose.So%EF%AC%81a.pdf 000041619 980__ $$aResearch Week 000041619 981__ $$aPublished$$b2023-08-21