@article{IR, recid = {41621}, author = {Jonker, Sonnet and Louey, Samantha and Chen, Athena}, title = {Physiological responses and disposition of lipids following fetal Intralipid 20® infusion}, publisher = {Oregon Health and Science University}, address = {2023-08-21}, number = {IR}, abstract = {Premature infants are exposed to a high lipid environment at earlier developmental stages than is normal, either via fat-rich breastmilk or by intravenous lipid emulsion parenteral nutrition (PN). Premature infants receiving PN sometimes develop pathologies, including PN-associated liver disease (PNALD), lipid embolism of the lung, and increased cardiac stiffness. We studied physiological responses to Intralipid 20® and lipid disposition in the fetal blood, liver, lung, heart, and placenta in fetal sheep at 85-90% of gestation (equivalent to 36 weeks in humans), eliminating confounding factors associated with preterm birth.}, url = {http://digitalcollections.ohsu.edu/record/41621}, doi = {https://doi.org/10.6083/bpxhc41621}, }