TY  - GEN
N2  - Premature infants are exposed to a high lipid environment at earlier developmental stages than is normal, either via fat-rich breastmilk or by intravenous lipid emulsion parenteral nutrition (PN). Premature infants receiving PN sometimes develop pathologies, including PN-associated liver disease (PNALD), lipid embolism of the lung, and increased cardiac stiffness. We studied physiological responses to Intralipid 20® and lipid disposition in the fetal blood, liver, lung, heart, and placenta in fetal sheep at 85-90% of gestation (equivalent to 36 weeks in humans), eliminating confounding factors associated with preterm birth.
DO  - 10.6083/bpxhc41621
DO  - doi
AB  - Premature infants are exposed to a high lipid environment at earlier developmental stages than is normal, either via fat-rich breastmilk or by intravenous lipid emulsion parenteral nutrition (PN). Premature infants receiving PN sometimes develop pathologies, including PN-associated liver disease (PNALD), lipid embolism of the lung, and increased cardiac stiffness. We studied physiological responses to Intralipid 20® and lipid disposition in the fetal blood, liver, lung, heart, and placenta in fetal sheep at 85-90% of gestation (equivalent to 36 weeks in humans), eliminating confounding factors associated with preterm birth.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Physiological responses and disposition of lipids following fetal Intralipid 20® infusion
DA  - 2023-08-21
AU  - Jonker, Sonnet
AU  - Louey, Samantha
AU  - Chen, Athena
L1  - https://digitalcollections.ohsu.edu/record/41621/files/ResearchWeek.2023.Jonker.Sonnet.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-08-21
ID  - 41621
L4  - https://digitalcollections.ohsu.edu/record/41621/files/ResearchWeek.2023.Jonker.Sonnet.pdf
KW  - Infant, Premature
KW  - Parenteral Nutrition
KW  - Lipids
KW  - Fetal Research
KW  - Fat Emulsions, Intravenous
KW  - Infant, Newborn
KW  - Pregnancy
KW  - Milk, Human
KW  - Liver Diseases
KW  - Embolism
KW  - nutrition
KW  - PN-associated liver disease
KW  - PNALD
KW  - lipid embolism
KW  - breastmilk
TI  - Physiological responses and disposition of lipids following fetal Intralipid 20® infusion
Y1  - 2023-08-21
L2  - https://digitalcollections.ohsu.edu/record/41621/files/ResearchWeek.2023.Jonker.Sonnet.pdf
LK  - https://digitalcollections.ohsu.edu/record/41621/files/ResearchWeek.2023.Jonker.Sonnet.pdf
UR  - https://digitalcollections.ohsu.edu/record/41621/files/ResearchWeek.2023.Jonker.Sonnet.pdf
ER  -