000041621 001__ 41621
000041621 005__ 20240415090700.0
000041621 0247_ $$2doi$$a10.6083/bpxhc41621
000041621 037__ $$aIR
000041621 041__ $$aeng
000041621 245__ $$aPhysiological responses and disposition of lipids following fetal Intralipid 20® infusion
000041621 260__ $$bOregon Health and Science University
000041621 269__ $$a2023-08-21
000041621 336__ $$aAbstract
000041621 520__ $$aPremature infants are exposed to a high lipid environment at earlier developmental stages than is normal, either via fat-rich breastmilk or by intravenous lipid emulsion parenteral nutrition (PN). Premature infants receiving PN sometimes develop pathologies, including PN-associated liver disease (PNALD), lipid embolism of the lung, and increased cardiac stiffness. We studied physiological responses to Intralipid 20® and lipid disposition in the fetal blood, liver, lung, heart, and placenta in fetal sheep at 85-90% of gestation (equivalent to 36 weeks in humans), eliminating confounding factors associated with preterm birth.
000041621 540__ $$fCC BY
000041621 542__ $$fIn copyright - joint owners
000041621 650__ $$aInfant, Premature$$020785
000041621 650__ $$aParenteral Nutrition$$023606
000041621 650__ $$aLipids$$021539
000041621 650__ $$aFetal Research$$034449
000041621 650__ $$aFat Emulsions, Intravenous$$018903
000041621 650__ $$aInfant, Newborn$$020782
000041621 650__ $$aPregnancy$$024523
000041621 650__ $$aMilk, Human$$022322
000041621 650__ $$aLiver Diseases$$021588
000041621 650__ $$aEmbolism$$018334
000041621 6531_ $$anutrition
000041621 6531_ $$aPN-associated liver disease
000041621 6531_ $$aPNALD
000041621 6531_ $$alipid embolism
000041621 6531_ $$abreastmilk
000041621 692__ $$aCenter for Developmental Health$$041383
000041621 7001_ $$aJonker, Sonnet$$uOregon Health and Science University$$041354
000041621 7001_ $$aLouey, Samantha$$uOregon Health and Science University$$041354
000041621 7001_ $$aChen, Athena$$uOregon Health and Science University$$041354
000041621 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000041621 8564_ $$97fec2dd9-1eba-4ae2-998e-ad0ea42bf168$$s68576$$uhttps://digitalcollections.ohsu.edu/record/41621/files/ResearchWeek.2023.Jonker.Sonnet.pdf
000041621 980__ $$aResearch Week
000041621 981__ $$aPublished$$b2023-08-21